Karl J Lewis
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Explore the profile of Karl J Lewis including associated specialties, affiliations and a list of published articles.
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13
Citations
92
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Recent Articles
1.
Wright C, Lewis K, Semon K, Yi X, Reyes Fernandez P, Rust K, et al.
J Bone Miner Res
. 2024 Mar;
39(3):298-314.
PMID: 38477790
Osteocytes sense and respond to mechanical force by controlling the activity of other bone cells. However, the mechanisms by which osteocytes sense mechanical input and transmit biological signals remain unclear....
2.
Matthews M, Cook E, Naguib N, Wiesner U, Lewis K
Bone
. 2023 Jun;
174:116830.
PMID: 37327917
Osteocytes are the resident mechanosensory cells in bone. They are responsible for skeletal homeostasis and adaptation to mechanical cues. Integrin proteins play a prominent role in osteocyte mechanotransduction, but the...
3.
Buettmann E, Chlebek C, Lockard C, Clayton S, Lewis K, Collins K
J Orthop Res
. 2023 May;
41(8):1643-1652.
PMID: 37163368
Social media usage, particularly Twitter, among scientists in academia has increased in recent years. However, Twitter's use in scholarly post-publication dissemination of orthopaedic research and musculoskeletal advocacy remains low. To...
4.
Lewis K, Boorman-Padgett J, Castaneda M, Spray D, Thi M, Schaffler M
J Vis Exp
. 2023 Mar;
(192).
PMID: 36912542
Bone tissue is exquisitely sensitive to differences in mechanical load magnitude. Osteocytes, dendritic cells that form a syncytium throughout the bone, are responsible for the mechanosensory function of bone tissue....
5.
Reyes Fernandez P, Wright C, Masterson A, Yi X, Tellman T, Bonteanu A, et al.
Biomolecules
. 2022 Dec;
12(12).
PMID: 36551284
Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering elements" (TEs) spanning the pericellular space of osteocytes and transmitting...
6.
7.
Lewis K
Bone
. 2021 Aug;
153:116136.
PMID: 34339908
Osteocytes are embedded dendritic bone cells; by virtue of their position in bone tissue, ability to coordinate bone building osteoblasts and resorbing osteoclasts, and sensitivity to tissue level mechanical loading,...
8.
Lewis K, Cabahug-Zuckerman P, Boorman-Padgett J, Basta-Pljakic J, Louie J, Stephen S, et al.
Bone
. 2021 Jun;
152:116072.
PMID: 34171514
Microstructural adaptation of bone in response to mechanical stimuli is diminished with estrogen deprivation. Here we tested in vivo whether ovariectomy (OVX) alters the acute response of osteocytes, the principal...
9.
The mTORC2 Component Rictor Is Required for Load-Induced Bone Formation in Late-Stage Skeletal Cells
Lewis K, Yi X, Wright C, Pemberton E, Bullock W, Thompson W, et al.
JBMR Plus
. 2020 Jul;
4(7):e10366.
PMID: 32666017
Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as...
10.
Alliston T, Foucher K, Frederick B, Hernandez C, Iatridis J, Kozloff K, et al.
J Orthop Res
. 2020 Apr;
38(8):1661-1665.
PMID: 32267012
No abstract available.