Karina Teelen
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Explore the profile of Karina Teelen including associated specialties, affiliations and a list of published articles.
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37
Citations
1636
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Recent Articles
1.
Mahamar A, Vanheer L, Smit M, Sanogo K, Sinaba Y, Niambele S, et al.
Lancet Microbe
. 2024 Dec;
6(2):100966.
PMID: 39701119
Background: Triple artemisinin-based combination therapies (TACTs) can delay the spread of antimalarial drug resistance. Artesunate-amodiaquine is widely used for uncomplicated Plasmodium falciparum malaria. We therefore aimed to determine the safety...
2.
Blanken S, Barry A, Lanke K, Guelbeogo M, Ouedraogo A, Soulama I, et al.
EBioMedicine
. 2024 Jun;
105:105190.
PMID: 38901148
Background: Plasmodium blood-stage parasites balance asexual multiplication with gametocyte development. Few studies link these dynamics with parasite genetic markers in vivo; even fewer in longitudinally monitored infections. Environmental influences on...
3.
Inklaar M, de Jong R, Bekkering E, Nagaoka H, Fennemann F, Teelen K, et al.
NPJ Vaccines
. 2023 Dec;
8(1):186.
PMID: 38086855
Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from becoming infectious. While the Pro-domain and first of fourteen...
4.
van der Boor S, Alkema M, van Gemert G, Teelen K, van de Vegte-Bolmer M, Walk J, et al.
BMC Med
. 2023 Apr;
21(1):137.
PMID: 37024868
Background: Whole sporozoite immunization under chemoprophylaxis (CPS regime) induces long-lasting sterile homologous protection in the controlled human malaria infection model using Plasmodium falciparum strain NF54. The relative proficiency of liver-stage...
5.
Ivanochko D, Fabra-Garcia A, Teelen K, van de Vegte-Bolmer M, van Gemert G, Newton J, et al.
Immunity
. 2023 Feb;
56(2):420-432.e7.
PMID: 36792575
Pfs230 is essential for Plasmodium falciparum transmission to mosquitoes and is the protein targeted by the most advanced malaria-transmission-blocking vaccine candidate. Prior understanding of functional epitopes on Pfs230 is based...
6.
Fabra-Garcia A, Hailemariam S, de Jong R, Janssen K, Teelen K, van de Vegte-Bolmer M, et al.
Immunity
. 2023 Feb;
56(2):406-419.e7.
PMID: 36792574
Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that interrupt malaria parasite development in the mosquito, thereby blocking onward transmission, and provide a much-needed tool for malaria control and elimination....
7.
Tebeje S, Chali W, Hailemeskel E, Ramjith J, Gashaw A, Ashine T, et al.
Front Cell Infect Microbiol
. 2023 Feb;
12:1106369.
PMID: 36726645
Naturally acquired antibodies may reduce the transmission of gametocytes to mosquitoes. Here, we investigated associations between antibody prevalence and infectivity to mosquitoes. A total of 368 microscopy confirmed symptomatic patients...
8.
van der Boor S, Smit M, van Beek S, Ramjith J, Teelen K, van de Vegte-Bolmer M, et al.
Lancet Infect Dis
. 2022 Aug;
22(11):1596-1605.
PMID: 35963275
Background: Malaria elimination requires interruption of the highly efficient transmission of Plasmodium parasites by mosquitoes. TB31F is a humanised monoclonal antibody that binds the gamete surface protein Pfs48/45 and inhibits...
9.
de Jong R, Alkema M, Oulton T, Dumont E, Teelen K, Nakajima R, et al.
Front Immunol
. 2022 Aug;
13:930956.
PMID: 35924245
Individuals infected with develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes. However, there is currently limited knowledge on the immunogenicity...
10.
de Jong R, Singh S, Teelen K, van de Vegte-Bolmer M, van Gemert G, Stone W, et al.
Front Immunol
. 2022 Jul;
13:909060.
PMID: 35812379
Malaria transmission blocking vaccines (TBV) aim to induce antibodies that can interrupt development in the mosquito midgut and thereby prevent onward malaria transmission. A limited number of TBV candidates have...