Karina Cuanalo-Contreras
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Explore the profile of Karina Cuanalo-Contreras including associated specialties, affiliations and a list of published articles.
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10
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266
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Recent Articles
1.
Scior T, Cuanalo-Contreras K, Islas A, Martinez-Laguna Y
Viruses
. 2023 May;
15(5).
PMID: 37243142
In this study, we describe the input data and processing steps to find antiviral lead compounds by a virtual screen. Two-dimensional and three-dimensional filters were designed based on the X-ray...
2.
Cuanalo-Contreras K, Schulz J, Mukherjee A, Park K, Armijo E, Soto C
Front Aging Neurosci
. 2023 Feb;
14:1090109.
PMID: 36778589
Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive...
3.
Mukherjee A, Cuanalo-Contreras K, Sood A, Soto C
Biochem Biophys Rep
. 2022 Aug;
31:101311.
PMID: 36032402
Calcineurin (CaN) is a calcium/calmodulin-dependent serine/threonine phosphatase with a crucial role in cellular homeostasis. It is also the target of the Food and Drug Administration (FDA) approved immunosuppressant drugs FK506...
4.
Cuanalo-Contreras K, Benkmann D
Altern Lab Anim
. 2022 Feb;
50(1):62-70.
PMID: 35184611
testing has been the gold standard for preclinical drug development and toxicology. However, animal-based methods often lack human relevance and have a low predictability rate, not to mention the enormous...
5.
Cuanalo-Contreras K, Moreno-Gonzalez I
Int J Mol Sci
. 2019 Sep;
20(19).
PMID: 31547084
Proteins play crucial and diverse roles within the cell. To exert their biological function they must fold to acquire an appropriate three-dimensional conformation. Once their function is fulfilled, they need...
6.
Meiyazhagan A, Aliyan A, Ayyappan A, Moreno-Gonzalez I, Susarla S, Yazdi S, et al.
ACS Appl Mater Interfaces
. 2018 Oct;
10(42):36275-36283.
PMID: 30270613
Luminescent carbon dots (Cdots) synthesized using inexpensive precursors have inspired tremendous research interest because of their superior properties and applicability in various fields. In this work, we report a simple,...
7.
Dhouafli Z, Cuanalo-Contreras K, Hayouni E, Mays C, Soto C, Moreno-Gonzalez I
Cell Mol Life Sci
. 2018 Jul;
75(19):3521-3538.
PMID: 30030591
Protein misfolding and aggregation into fibrillar deposits is a common feature of a large group of degenerative diseases affecting the central nervous system or peripheral organs, termed protein misfolding disorders...
8.
Cuanalo-Contreras K, Park K, Mukherjee A, Pena L, Soto C
Biochem Biophys Res Commun
. 2016 Nov;
482(1):62-67.
PMID: 27810360
Recent evidence suggests that during aging there is widespread accumulation of aggregated insoluble proteins, even in the absence of pathological conditions. Pharmacological manipulation of protein aggregation might be helpful to...
9.
Cuanalo-Contreras K, Mukherjee A, Soto C
Int J Cell Biol
. 2013 Dec;
2013:638083.
PMID: 24348562
The misfolding, aggregation, and tissue accumulation of proteins are common events in diverse chronic diseases, known as protein misfolding disorders. Many of these diseases are associated with aging, but the...
10.
Scior T, Bender A, Tresadern G, Medina-Franco J, Martinez-Mayorga K, Langer T, et al.
J Chem Inf Model
. 2012 Mar;
52(4):867-81.
PMID: 22435959
The aim of virtual screening (VS) is to identify bioactive compounds through computational means, by employing knowledge about the protein target (structure-based VS) or known bioactive ligands (ligand-based VS). In...