Karin Diggle
Overview
Explore the profile of Karin Diggle including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
107
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kim H, Rosenthal S, Liu X, Miciano C, Hou X, Miller M, et al.
J Hepatol
. 2024 Nov;
PMID: 39522884
Background & Aims: Metabolic dysfunction-associated steatotic liver disease ranges from metabolic dysfunction-associated steatotic liver (MASL) to metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis. Transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic...
2.
Kim H, Lee W, Liu X, Jang H, Sakane S, Carvalho-Gontijo Weber R, et al.
STAR Protoc
. 2024 Jun;
5(2):103111.
PMID: 38833372
Currently, there is no effective treatment for obesity and alcohol-associated liver diseases, partially due to the lack of translational human models. Here, we present a protocol to generate 3D human...
3.
Osna N, Tikhanovich I, Ortega-Ribera M, Mueller S, Zheng C, Mueller J, et al.
Biomolecules
. 2024 Apr;
14(4.
PMID: 38672422
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and...
4.
Li N, Li X, Ding Y, Liu X, Diggle K, Kisseleva T, et al.
Biomedicines
. 2023 Dec;
11(12.
PMID: 38137501
Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they...
5.
Kim H, Sakane S, Eguileor A, Carvalho Gontijo Weber R, Lee W, Liu X, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Sep;
17(1):93-106.
PMID: 37743012
Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or...
6.
Liu X, Lam K, Zhao H, Sakane S, Kim H, Eguileor A, et al.
STAR Protoc
. 2023 Jul;
4(3):102391.
PMID: 37405925
Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and...
7.
Pouyanfard S, Meshgin N, Cruz L, Diggle K, Hashemi H, Pham T, et al.
Stem Cells
. 2021 Aug;
39(12):1701-1717.
PMID: 34460131
With an increasing number of patients with degenerative hepatic diseases, such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can...
8.
Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T, Brenner D, et al.
Arch Clin Biomed Res
. 2020 Nov;
4(5):561-580.
PMID: 33210080
Aim: To investigate the therapeutic effect of FZHY on hepatic fibrosis in mice and to determine the mechanism of its action. Methods: Wild type mice were subjected to toxic (carbon...
9.
Liu X, Rosenthal S, Meshgin N, Baglieri J, Musallam S, Diggle K, et al.
Hepatol Commun
. 2020 Apr;
4(4):606-626.
PMID: 32258954
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar....
10.
Kim I, Xu J, Liu X, Koyama Y, Ma H, Diggle K, et al.
Age (Dordr)
. 2016 Sep;
38(4):291-302.
PMID: 27578257
We aimed to investigate whether aging increases the susceptibility of hepatic and renal inflammation or fibrosis in response to high-fat diet (HFD) and explore the underlying genetic alterations. Middle (10 ...