Kari Thrasher
Overview
Explore the profile of Kari Thrasher including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
3
Citations
55
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mangkalaphiban K, Fu L, Du M, Thrasher K, Keeling K, Bedwell D, et al.
Nat Commun
. 2024 Mar;
15(1):2486.
PMID: 38509072
Protein synthesis terminates when a stop codon enters the ribosome's A-site. Although termination is efficient, stop codon readthrough can occur when a near-cognate tRNA outcompetes release factors during decoding. Seeking...
2.
Chen J, Thrasher K, Fu L, Wang W, Aghamohammadzadeh S, Wen H, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Apr;
324(6):L756-L770.
PMID: 37014818
Ten percent of cystic fibrosis (CF) patients carry a premature termination codon (PTC); no mutation-specific therapies exist for these individuals. ELX-02, a synthetic aminoglycoside, suppresses translation termination at PTCs (i.e.,...
3.
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Sharma J, Du M, Wong E, Mutyam V, Li Y, Chen J, et al.
Nat Commun
. 2021 Jul;
12(1):4358.
PMID: 34272367
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination...