Karen Pickthorn
Overview
Explore the profile of Karen Pickthorn including associated specialties, affiliations and a list of published articles.
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10
Citations
159
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0
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Recent Articles
1.
Olafson E, Tonietto M, Klein G, Teng E, Stephens A, Russell D, et al.
J Nucl Med
. 2025 Jan;
66(2):277-285.
PMID: 39746756
Alzheimer disease (AD) is characterized by the accumulation of tau neurofibrillary tangles that can be labeled with PET tracers. Multiple tau PET tracers have been used in clinical studies, including...
2.
Bressler N, Freund K, Bakri S, Kim J, Ferrara D, Brittain C, et al.
JAMA Ophthalmol
. 2024 Jun;
142(8):772-776.
PMID: 38900484
Importance: Intraocular pressure (IOP) elevations of clinical relevance have been observed after the commonly used 0.05-mL volume for intravitreous injections. However, more recently approved intravitreous agents involve volumes from 0.07...
3.
Teng E, Li Y, Manser P, Pickthorn K, Butcher B, Blendstrup M, et al.
Alzheimers Dement (Amst)
. 2023 Jun;
15(2):e12452.
PMID: 37325545
Introduction: Prior observational work in a heterogeneous cohort of participants with mild cognitive impairment suggests the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) may have greater sensitivity for functional...
4.
Teng E, Manser P, Pickthorn K, Brunstein F, Blendstrup M, Sanabria Bohorquez S, et al.
JAMA Neurol
. 2022 Jun;
79(8):758-767.
PMID: 35696185
Importance: Neurofibrillary tangles composed of aggregated tau protein are one of the neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease severity. Monoclonal antibodies targeting tau may have...
5.
Teng E, Manser P, Sanabria Bohorquez S, Wildsmith K, Pickthorn K, Baker S, et al.
Alzheimers Res Ther
. 2021 Dec;
13(1):196.
PMID: 34852837
Background: The role and implementation of tau PET imaging for predicting subsequent cognitive decline in Alzheimer's disease (AD) remains uncertain. This study was designed to evaluate the relationship between baseline...
6.
Shen J, Xiao J, Pickthorn K, Huang S, Bell G, Vick A, et al.
J Clin Pharmacol
. 2014 Apr;
54(10):1125-33.
PMID: 24752908
AMG 416 is a novel peptide agonist of the calcium-sensing receptor. In support of the clinical development program, a pharmacokinetic (PK)/pharmacodynamic (PD) model was developed to describe the relationship between...
7.
Martin K, Bell G, Pickthorn K, Huang S, Vick A, Hodsman P, et al.
Nephrol Dial Transplant
. 2013 Nov;
29(2):385-92.
PMID: 24235081
Context: Velcalcetide, also known as AMG 416, is a novel, long-acting selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism...
8.
Martin K, Pickthorn K, Huang S, Block G, Vick A, Mount P, et al.
Kidney Int
. 2013 Aug;
85(1):191-7.
PMID: 23903371
AMG 416 (velcalcetide), a novel peptide agonist of the calcium-sensing receptor, lowers plasma parathyroid hormone in preclinical uremic animal models and in normal healthy individuals. Here, we studied its efficacy...
9.
Moodie J, Bisley E, Huang S, Pickthorn K, Bell G
Pain Med
. 2013 Apr;
14(6):916-24.
PMID: 23565709
Objective: KAI-1678, a novel inhibitor of the interaction of the epsilon isoform of protein kinase C (εPKC) with its intracellular receptor, has demonstrated activity in countering hyperalgesia in several models...
10.
Cousins M, Pickthorn K, Huang S, Critchley L, Bell G
Pain Med
. 2013 Feb;
14(4):533-40.
PMID: 23438341
Objective: Postherpetic neuralgia (PHN) occurs in approximately 10-20% of patients with herpes zoster, and the risk increases with age. In this clinical trial, we evaluated the analgesic properties of KAI-1678-an...