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Karen McLachlan

Explore the profile of Karen McLachlan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 163
Followers 0
Related Specialties
Oncology
Pediatrics
Allergy & Immunology
Top 10 Co-Authors
Alla Lisyanskaya
Amit M Oza
Yaroslav Shparyk
Igor Bondarenko
Xianjun Cao
Daleen Thomas
Ana Oaknin
Robert Poka
Andreia Cristina de Melo
Domenica Lorusso
Published In
J Immunol
Lancet Oncol
Cancer Biol Ther
Acta Paediatr
Arch Dis Child
Affiliations
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Recent Articles
1.
Rucaparib versus chemotherapy for treatment of relapsed ovarian cancer with deleterious BRCA1 or BRCA2 mutation (ARIEL4): final results of an international, open-label, randomised, phase 3 trial
Oza A, Lisyanskaya A, Fedenko A, de Melo A, Shparyk Y, Rakhmatullina I, et al.
Lancet Oncol . 2025 Feb; 26(2):249-264. PMID: 39914419
Background: In the ARIEL4 trial of rucaparib versus standard-of-care chemotherapy in patients with relapsed BRCA-mutated ovarian carcinoma, the primary endpoint was met, showing improved investigator-assessed progression-free survival with rucaparib. Here,...
2.
Rucaparib versus standard-of-care chemotherapy in patients with relapsed ovarian cancer and a deleterious BRCA1 or BRCA2 mutation (ARIEL4): an international, open-label, randomised, phase 3 trial
Kristeleit R, Lisyanskaya A, Fedenko A, Dvorkin M, de Melo A, Shparyk Y, et al.
Lancet Oncol . 2022 Mar; 23(4):465-478. PMID: 35298906
Background: Few prospective studies have compared poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors to chemotherapy for the treatment of BRCA1-mutated or BRCA2-mutated ovarian carcinoma. We aimed to assess rucaparib versus platinum-based and...
3.
Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study
Matthews Y, Dean F, Lim M, McLachlan K, Rigby A, Solanki G, et al.
Arch Dis Child . 2017 Mar; 102(8):715-721. PMID: 28356250
Aim: To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. Methods: A national prospective population-based cohort study over 25 months....
4.
Correction: novel insights on human NK cells' immunological modalities revealed by gene expression profiling
Hanna J, Bechtel P, Zhai Y, Youssef F, McLachlan K, Mandelboim O
J Immunol . 2015 Feb; 194(5):2447-8. PMID: 25710959
No abstract available.
5.
Antibodies directed to alpha6beta4 highlight the adhesive and signaling functions of the integrin in breast cancer cell lines
Gabarra V, Cho S, Ramirez M, Ren Y, Chen L, Cheung A, et al.
Cancer Biol Ther . 2010 Jan; 9(6):437-45. PMID: 20061819
Integrin alpha6beta4 signaling interactions have been implicated in tumor progression, and beta4 expression has been linked to poor prognosis in certain breast cancer subtypes. We generated human antibodies to alpha6beta4...
6.
Functional characterization of integrin alpha6beta4 adhesion interactions using soluble integrin constructs reveals the involvement of different functional domains in the beta4 subunit
Chen L, Gabarra V, Cho S, Browning B, Cao X, Huet H, et al.
Cell Commun Adhes . 2008 Nov; 15(4):317-31. PMID: 18979297
Integrin alpha6beta4-mediated adhesion interactions play key roles in keratinocyte and epithelial tumor cell biology. In order to evaluate how alpha6beta4 adhesion interactions contribute to these important cellular processes, the authors...
7.
Thyroxine: cause and cure for headache
Shaikh M, Wickramasuriya N, McLachlan K, Stirling H, Kirk J
Acta Paediatr . 2006 Jul; 95(5):632-3. PMID: 16825155
No abstract available.
8.
Novel insights on human NK cells' immunological modalities revealed by gene expression profiling
Hanna J, Bechtel P, Zhai Y, Youssef F, McLachlan K, Mandelboim O
J Immunol . 2004 Nov; 173(11):6547-63. PMID: 15557145
As part of the innate immune system, human NK cells play a critical role early in the systemic host defense against pathogens and tumor cells. Recent studies suggest a more...