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Karen Colwill

Explore the profile of Karen Colwill including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 68
Citations 3437
Followers 0
Related Specialties
Cell Biology
General Medicine
Biochemistry
Top 10 Co-Authors
Anne-Claude Gingras
Tony Pawson
Adrian Pasculescu
Kento T Abe
Bhavisha Rathod
Steven J Drews
Freda Qi
Kevin Yau
Michelle A Hladunewich
Sheila F OBrien
Published In
Microbiol Spectr
Mol Cell Biol
JAMA Netw Open
J Virol
Can J Kidney Health Dis
Affiliations
Soon will be listed here.
Recent Articles
1.
mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity
Samaan P, Korosec C, Budylowski P, Chau S, Pasculescu A, Qi F, et al.
J Virol . 2025 Jan; :e0168524. PMID: 39887249
Importance: Our findings provide valuable insights into the potential contributions of mRNA vaccine-induced spike-specific T-cell responses to the durability of neutralizing antibody levels in both uninfected and hybrid immune recipients....
2.
Characterizing the SARS-CoV-2 antibody response and associations with patient factors: Serological profiling of participants enrolled in the GENCOV study
Morgan G, Fung C, Gingras A, Colwill K, Briollais L, Frangione E, et al.
Clin Biochem . 2024 Dec; 135():110859. PMID: 39645018
Introduction: The GENCOV study sought to evaluate serological differences between individuals with differing COVID-19 severity and outcomes. We assessed the SARS-CoV-2 antibody response of GENCOV participants cross-sectionally 1-, 6-, and...
3.
High SARS-CoV-2 seroincidence but low excess COVID mortality in Sierra Leone in 2020-2022
Osman A, Aimone A, Ansumana R, Bogoch I, Gelband H, Colwill K, et al.
PLOS Glob Public Health . 2024 Sep; 4(9):e0003411. PMID: 39255307
While SARS-CoV-2 infection appears to have spread widely throughout Africa, documentation of associated mortality is limited. We implemented a representative serosurvey in one city of Sierra Leone in Western Africa,...
4.
High-resolution quadrupole improves spectral purity and reduces interference from non-target ions in isobaric multiplexed quantitative proteomics
Zhang S, Le Blanc J, Larsen B, Colwill K, Burton L, Guna M, et al.
Anal Chim Acta . 2024 Sep; 1325:343135. PMID: 39244297
Background: Mass spectrometry (MS)-based proteomics is a powerful tool for identifying and quantifying proteins. However, chimeric spectra caused by the fragmentation of multiple precursors within the same isolation window impair...
5.
Seroprevalence of SARS-CoV-2 antibodies among children receiving primary care in Toronto, Ontario
Aglipay M, Kwong J, Colwill K, Gringas A, Tuite A, Mamdani M, et al.
Can J Public Health . 2024 Aug; 115(6):913-923. PMID: 39168962
Objective: Characterizing the seroprevalence of SARS-CoV-2 antibodies in children is needed to optimize the COVID-19 public health response. We quantified the seroprevalence of SARS-CoV-2 infection-acquired antibodies and vaccine-acquired antibodies among...
6.
Declining Levels of Neutralizing Antibodies to SARS-CoV-2 Omicron Variants Are Enhanced by Hybrid Immunity and Original/Omicron Bivalent Vaccination
Walmsley S, Nabipoor M, Qi F, Lovblom L, Ravindran R, Colwill K, et al.
Vaccines (Basel) . 2024 Jun; 12(6). PMID: 38932293
We determined neutralizing antibody levels to the ancestral Wuhan SARS-CoV-2 strain and three Omicron variants, namely BA.5, XBB.1.5, and EG.5, in a heavily vaccinated cohort of 178 adults 15-19 months...
7.
Hybrid immunity from severe acute respiratory syndrome coronavirus 2 infection and vaccination in Canadian adults: A cohort study
Brown P, Fu S, Newcombe L, Tang X, Nagelkerke N, Birnboim H, et al.
Elife . 2024 Jun; 13. PMID: 38916134
Background: Few national-level studies have evaluated the impact of 'hybrid' immunity (vaccination coupled with recovery from infection) from the Omicron variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)....
8.
Enhancing detection of SARS-CoV-2 re-infections using longitudinal sero-monitoring: demonstration of a methodology in a cohort of people experiencing homelessness in Toronto, Canada
Richard L, Nisenbaum R, Colwill K, Mishra S, Dayam R, Liu M, et al.
BMC Infect Dis . 2024 Feb; 24(1):125. PMID: 38302878
Background: Accurate estimation of SARS-CoV-2 re-infection is crucial to understanding the connection between infection burden and adverse outcomes. However, relying solely on PCR testing results in underreporting. We present a...
9.
Humoral Response Following 3 Doses of mRNA COVID-19 Vaccines in Patients With Non-Dialysis-Dependent CKD: An Observational Study
Enilama O, Yau K, Er L, Atiquzzaman M, Oliver M, Romney M, et al.
Can J Kidney Health Dis . 2024 Jan; 11:20543581231224127. PMID: 38292817
Background: Chronic kidney disease (CKD) is associated with a lower serologic response to vaccination compared to the general population. There is limited information regarding the serologic response to coronavirus disease...
10.
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity
Nantel S, Sheikh-Mohamed S, Chao G, Kurtesi A, Hu Q, Wood H, et al.
Mucosal Immunol . 2024 Jan; 17(2):201-210. PMID: 38278415
Our understanding of the quality of cellular and humoral immunity conferred by COVID-19 vaccination alone versus vaccination plus SARS-CoV-2 breakthrough (BT) infection remains incomplete. While the current (2023) SARS-CoV-2 immune...