Karel Stepka
Overview
Explore the profile of Karel Stepka including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
63
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0
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Recent Articles
1.
Pavlatovska B, Machalkova M, Brisudova P, Pruska A, Stepka K, Michalek J, et al.
Front Oncol
. 2020 Dec;
10:581365.
PMID: 33344237
Colorectal cancer (CRC) is a disease with constantly increasing incidence and high mortality. The treatment efficacy could be curtailed by drug resistance resulting from poor drug penetration into tumor tissue...
2.
Machalkova M, Pavlatovska B, Michalek J, Pruska A, Stepka K, Necasova T, et al.
Anal Chem
. 2019 Oct;
91(21):13475-13484.
PMID: 31584797
In this paper, we present an easy-to-follow procedure for the analysis of tissue sections from 3D cell cultures (spheroids) by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) and laser...
3.
Michalek J, Stepka K, Kozubek M, Navratilova J, Pavlatovska B, Machalkova M, et al.
Microsc Microanal
. 2019 Oct;
25(6):1311-1322.
PMID: 31571549
Spheroids-three-dimensional aggregates of cells grown from a cancer cell line-represent a model of living tissue for chemotherapy investigation. Distribution of chemotherapeutics in spheroid sections was determined using the matrix-assisted laser...
4.
Eiselleova L, Lukjanov V, Farkas S, Svoboda D, Stepka K, Koutna I
Stem Cells Int
. 2019 Mar;
2019:1375807.
PMID: 30863449
The eukaryotic nucleus is a highly complex structure that carries out multiple functions primarily needed for gene expression, and among them, transcription seems to be the most fundamental. Diverse approaches...
5.
Kotrbova A, Stepka K, Maska M, Palenik J, Ilkovics L, Klemova D, et al.
J Extracell Vesicles
. 2019 Feb;
8(1):1560808.
PMID: 30719239
Extracellular vesicles (EVs) function as important conveyers of information between cells and thus can be exploited as drug delivery systems or disease biomarkers. Transmission electron microscopy (TEM) remains the gold...
6.
Stejskal S, Stepka K, Tesarova L, Stejskal K, Matejkova M, Simara P, et al.
Cell Cycle
. 2015 Dec;
14(24):3851-63.
PMID: 26645646
The incorporation of histone H3 with an acetylated lysine 56 (H3K56ac) into the nucleosome is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication...
7.
Stepka K, Matula P, Matula P, Worz S, Rohr K, Kozubek M
Cytometry A
. 2015 Jun;
87(8):759-72.
PMID: 26033916
Reliable 3D detection of diffraction-limited spots in fluorescence microscopy images is an important task in subcellular observation. Generally, fluorescence microscopy images are heavily degraded by noise and non-specifically stained background,...