Kaoru Kiguchi
Overview
Explore the profile of Kaoru Kiguchi including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
1642
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Recent Articles
11.
Rodriguez B, Li X, Kiguchi K, DiGiovanni J, Unger E, Cui Z
Nanomedicine (Lond)
. 2012 Feb;
7(4):475-91.
PMID: 22296186
Aim: Previously, it was shown that treatment of tumor-bearing mice with an RNA replicase-based plasmid that produces dsRNA when transfected into tumor cells significantly inhibited the tumor growth. In the...
12.
Tian J, Lambertz I, Berton T, Rundhaug J, Kiguchi K, Shirley S, et al.
Mol Carcinog
. 2011 Oct;
51(12):973-83.
PMID: 22006370
Studies show that elevated insulin-like growth factor-1 (IGF-1) levels are associated with an increased risk of breast cancer; however, mechanisms through which IGF-1 promotes mammary tumorigenesis in vivo have not...
13.
Sloat B, Kiguchi K, Xiao G, DiGiovanni J, Maury W, Cui Z
J Control Release
. 2011 Sep;
157(1):94-102.
PMID: 21907253
Transcutaneous DNA immunization is an attractive immunization approach. Previously, we reported that transcutaneous immunization by applying plasmid DNA onto a skin area wherein the hair follicles had been induced into...
14.
Sandoval M, Sloat B, Lansakara-P D, Kumar A, Rodriguez B, Kiguchi K, et al.
J Control Release
. 2011 Aug;
157(2):287-96.
PMID: 21871505
Previously, it was shown that a novel 4-(N)-stearoyl gemcitabine nanoparticle formulation was more effective than gemcitabine hydrochloride in controlling the growth of model mouse or human tumors pre-established in mice....
15.
Sloat B, Sandoval M, Li D, Chung W, Lansakara-P D, Proteau P, et al.
Int J Pharm
. 2011 Mar;
409(1-2):278-88.
PMID: 21371545
Gemcitabine (Gemzar(®)) is the first line treatment for pancreatic cancer and often used in combination therapy for non-small cell lung, ovarian, and metastatic breast cancers. Although extremely toxic to a...
16.
Kiguchi K, Kitamura T, Moore T, Rumi M, Chang H, Treece D, et al.
Cancer Prev Res (Phila)
. 2010 Aug;
3(8):940-52.
PMID: 20682802
The erbB family of receptor tyrosine kinases are known to play important roles in normal epithelial development and epithelial neoplasia. Considerable evidence also suggests that signaling through the epidermal growth...
17.
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation
Kim D, Kataoka K, Rao D, Kiguchi K, Cotsarelis G, DiGiovanni J
Cancer Res
. 2009 Sep;
69(19):7587-94.
PMID: 19738054
The initiation stage of mouse skin carcinogenesis involves the induction of mutations in keratinocyte stem cells (KSC), which confers a selective growth advantage allowing clonal expansion during tumor promotion. Targeted...
18.
Abel E, Angel J, Kiguchi K, DiGiovanni J
Nat Protoc
. 2009 Aug;
4(9):1350-62.
PMID: 19713956
For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors. In the traditional two-stage...
19.
Kim D, Kataoka K, Sano S, Connolly K, Kiguchi K, DiGiovanni J
Mol Carcinog
. 2009 Mar;
48(10):873-85.
PMID: 19309000
Bcl-x(L) is one of several antiapoptotic proteins regulated by signal transducer and activator of transcription 3 (Stat3). We have recently shown that Stat3 is required for chemically induced and ultraviolet...
20.
Moral M, Segrelles C, Lara M, Martinez-Cruz A, Lorz C, Santos M, et al.
Cancer Res
. 2009 Jan;
69(3):1099-108.
PMID: 19176372
Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia with poor prognosis and survival that frequently displays Akt overactivation. Here we show that mice displaying constitutive Akt...