Kam S Ho-Mok
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Explore the profile of Kam S Ho-Mok including associated specialties, affiliations and a list of published articles.
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10
Citations
288
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Recent Articles
1.
Koelink P, Gomez-Mellado V, Duijst S, van Roest M, Meisner S, Ho-Mok K, et al.
J Crohns Colitis
. 2024 Feb;
18(7):1134-1146.
PMID: 38366839
Aims: Patients with mutations in ATP8B1 develop progressive familial intrahepatic cholestasis type 1 [PFIC1], a severe liver disease that requires life-saving liver transplantation. PFIC1 patients also present with gastrointestinal problems,...
2.
Gomez-Mellado V, Chang J, Ho-Mok K, Bernardino Morcillo C, Kersten R, Oude Elferink R, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293199
ATP8B1 is a phospholipid flippase that is deficient in patients with progressive familial intrahepatic cholestasis type 1 (PFIC1). PFIC1 patients suffer from severe liver disease but also present with dyslipidemia,...
3.
Gomez-Mellado V, Ho-Mok K, van der Mark V, van der Wel N, Grootemaat A, Verhoeven A, et al.
Cell Biochem Funct
. 2022 Sep;
40(8):914-925.
PMID: 36169099
ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P-type ATPases (P4-ATPase) subfamily. P4-ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry,...
4.
van der Mark V, Ghiboub M, Marsman C, Zhao J, van Dijk R, Hiralall J, et al.
Cell Mol Life Sci
. 2017 Feb;
74(7):1365.
PMID: 28175960
No abstract available.
5.
van der Mark V, Ghiboub M, Marsman C, Zhao J, van Dijk R, Hiralall J, et al.
Cell Mol Life Sci
. 2016 Sep;
74(4):715-730.
PMID: 27628304
P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time,...
6.
van der Mark V, De Jonge H, Chang J, Ho-Mok K, Duijst S, Vidovic D, et al.
Biochim Biophys Acta
. 2016 Jun;
1863(9):2280-8.
PMID: 27301931
Progressive familial intrahepatic cholestasis type 1 (PFIC1) is caused by mutations in the gene encoding the phospholipid flippase ATP8B1. Apart from severe cholestatic liver disease, many PFIC1 patients develop extrahepatic...
7.
van der Mark V, Rudi de Waart D, Ho-Mok K, Tabbers M, Voogt H, Oude Elferink R, et al.
Biochim Biophys Acta
. 2014 Sep;
1842(12 Pt A):2378-86.
PMID: 25239307
Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type 1...
8.
Folmer D, van der Mark V, Ho-Mok K, Oude Elferink R, Paulusma C
Hepatology
. 2009 Sep;
50(5):1597-605.
PMID: 19731236
Unlabelled: Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type 1 (BRIC1), forming a spectrum of cholestatic disease. Whereas PFIC1 is a...
9.
Paulusma C, Folmer D, Ho-Mok K, Rudi de Waart D, Hilarius P, Verhoeven A, et al.
Hepatology
. 2007 Oct;
47(1):268-78.
PMID: 17948906
Unlabelled: Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1. Previously, we have shown in mice that Atp8b1 deficiency leads to enhanced...
10.
Paulusma C, Groen A, Kunne C, Ho-Mok K, Spijkerboer A, Rudi de Waart D, et al.
Hepatology
. 2006 Jun;
44(1):195-204.
PMID: 16799980
Progressive familial intrahepatic cholestasis type 1 (PFIC1, Byler disease, OMIM 211600) is a severe inherited liver disease caused by mutations in ATP8B1. ATP8B1 is a member of the type 4...