Kalpit A Vora
Overview
Explore the profile of Kalpit A Vora including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
713
Followers
0
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Recent Articles
1.
Mukhopadhyay S, Manolaridis I, Warren C, Tang A, ODonnell G, Luo B, et al.
Vaccines (Basel)
. 2025 Jan;
13(1).
PMID: 39852814
The respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in children and adults. With nearly everyone infected by the age of five, there is an...
2.
Madhi S, Simoes E, Acevedo A, Novoa Pizarro J, Shepard J, Railkar R, et al.
J Infect Dis
. 2024 Nov;
PMID: 39601265
Background: Clesrovimab is an investigational monoclonal antibody with an extended half-life targeting site IV of the respiratory syncytial virus (RSV) fusion protein for the prevention of RSV disease in infants....
3.
Thambi N, Phuah J, Staupe R, Tobias L, Cao Y, McKelvey T, et al.
J Infect Dis
. 2024 Nov;
PMID: 39590882
Background: Clesrovimab is a human half-life extended mAb in phase 3 evaluation for the prevention of RSV disease in infants. ADA were observed at late time points in a phase...
4.
Xiao X, Wen Z, Chen Q, Shipman J, Kostas J, Reid J, et al.
J Virol
. 2023 Nov;
97(12):e0105223.
PMID: 38032197
Human metapneumovirus (hMPV) is a common pathogen causing lower respiratory tract infections worldwide and can develop severe symptoms in high-risk populations such as infants, the elderly, and immunocompromised patients. There...
5.
Phuah J, Maas B, Tang A, Zhang Y, Caro L, Railkar R, et al.
Biomed Pharmacother
. 2023 Nov;
169:115851.
PMID: 37976891
Background: Clesrovimab (MK-1654) is an investigational, half-life extended human monoclonal antibody (mAb) against RSV F glycoprotein in clinical trials as a prophylactic agent against RSV infection for infants. Methods: This...
6.
Li A, Swanson M, Sullivan N, Homan Y, Nahas D, Mukhopadhyay S, et al.
Bioanalysis
. 2023 Jul;
15(16):1049-1067.
PMID: 37515532
MK-1654 is a fully human monoclonal antibody with YTE mutations currently in phase III clinical trials for prophylactic use in protecting infants from human respiratory syncytial virus infection. We generated...
7.
Datta S, Chen D, Tavares A, Reyes-Robles T, Ryu K, Khan N, et al.
Cell Chem Biol
. 2023 Jul;
30(10):1313-1322.e7.
PMID: 37499664
Identifying virus-host interactions on the cell surface can improve our understanding of viral entry and pathogenesis. SARS-CoV-2, the causative agent of the COVID-19 disease, uses ACE2 as a receptor to...
8.
Staupe R, Lodge K, Thambi N, Toole D, Tamburino A, Chang D, et al.
Commun Biol
. 2022 Dec;
5(1):1399.
PMID: 36543997
In response to infection or immunization, antibodies are produced that provide protection against re-exposure with the same pathogen. These antibodies can persist at high titers for decades and are maintained...
9.
Xiao X, Fridman A, Zhang L, Pristatsky P, Durr E, Minnier M, et al.
Nat Commun
. 2022 May;
13(1):2546.
PMID: 35538099
Human metapneumovirus (hMPV) belongs to the Pneumoviridae family and is closely related to respiratory syncytial virus (RSV). The surface fusion (F) glycoprotein mediates viral fusion and is the primary target...
10.
Cavazzoni C, Hanson B, Podesta M, Bechu E, Clement R, Zhang H, et al.
Cell Rep
. 2022 Feb;
38(8):110399.
PMID: 35139367
Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain, germinal center (GC) reactions. However, the precise roles of these cells in the complex GC reaction remain...