Kalirajan Rajagopal
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Explore the profile of Kalirajan Rajagopal including associated specialties, affiliations and a list of published articles.
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21
Citations
74
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Recent Articles
1.
Balikai A, Kumar M, Rajagopal K, Alshehri M, Rab S, Nafady M, et al.
Med Chem
. 2025 Jan;
PMID: 39878110
Pyridine and its derivatives are six-membered aromatic rings containing nitrogen, which are abundant in nature and indispensable in studying heterocyclic chemistry. They constitute significant chemical substances with numerous applications. The...
2.
Islam M, Al-Imran M, Zehravi M, Sweilam S, Mortuza M, Gupta J, et al.
Animal Model Exp Med
. 2025 Jan;
PMID: 39843406
Background: Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are complex and challenging due to their intricate pathophysiology and limited treatment options. Methods: This review systematically sourced...
3.
Das S, Byran G, Biswas K, Rajagopal K
Curr Cancer Drug Targets
. 2025 Jan;
PMID: 39754759
Cancer manifests as uncontrolled cell proliferation. Tankyrase, a poly(ADP-ribose) polymerase member, is vital in Wnt signal transmission, making it a promising cancer therapy target. The Wnt/β-catenin pathway regulates critical biological...
4.
Arumugam M, Pachamuthu R, Rymbai E, Jha A, Rajagopal K, Kothandan R, et al.
Mol Divers
. 2024 Aug;
PMID: 39145879
The cysteine residues of Keap1 such as C151, C273, and C288 are critical for its repressor activity on Nrf2. However, to date, no molecules have been identified to covalently modify...
5.
Manya B, Kumar M, Rajagopal K, Hassan M, Rab S, Alshehri M, et al.
Chem Biodivers
. 2024 May;
21(8):e202400534.
PMID: 38771305
Pyrrole, with its versatile heterocyclic ring structure, serves as a valuable template for generating a diverse range of lead compounds with various pharmacophores. Researchers and scientists globally are intrigued by...
6.
Bhat A, Chakkittukandiyil A, Muthu S, Kotha S, Muruganandham S, Rajagopal K, et al.
Biochem Biophys Res Commun
. 2024 Feb;
703:149611.
PMID: 38354463
Uterine fibroid is the most common non-cancerous tumor with no satisfactory options for long-term pharmacological treatment. Fibroblast activation protein-α (FAP) is one of the critical enzymes that enhances the fibrosis...
7.
Chakkittukandiyil A, Chakraborty S, Kothandan R, Rymbai E, Muthu S, Vasu S, et al.
J Biomol Struct Dyn
. 2023 Sep;
42(20):10785-10799.
PMID: 37723871
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Drug repositioning is a process of finding new therapeutic applications for existing drugs. One of the methods in...
8.
Raman K, Rajagopal K, Ramesh B, Nallasivan P, Raja M, Jupudi S, et al.
Ann Med Surg (Lond)
. 2023 Jun;
85(6):2731-2742.
PMID: 37363478
The new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] that caused a viral disease with a high risk of mortality (coronavirus disease 2019) was found toward the end of...
9.
Rajagopal K, Kalusalingam A, Bharathidasan A, Sivaprakash A, Shanmugam K, Sundaramoorthy M, et al.
Molecules
. 2023 May;
28(10).
PMID: 37241915
Cancer is a condition marked by abnormal cell proliferation that has the potential to invade or indicate other health issues. Human beings are affected by more than 100 different types...
10.
Negi P, Lakshmanan K, Patel P, Rajagopal K, Byran G
Mini Rev Med Chem
. 2023 Feb;
23(18):1762-1771.
PMID: 36824002
Poly (ADP-ribose) polymerase 1 (PARP1) plays important roles in both DNA repair and transcription, and the interplay of these processes in relation to cellular function and disease states has not...