K Tottori
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Explore the profile of K Tottori including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
145
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Recent Articles
1.
Tottori K, Miwa T, Uwahodo Y, Yamada S, Nakai M, Oshiro Y, et al.
Neuropharmacology
. 2001 Dec;
41(8):976-88.
PMID: 11747902
The antidepressant-like activity of a novel compound, OPC-14523, was investigated in comparison with the conventional antidepressants, fluoxetine and imipramine. OPC-14523 bound with nanomolar affinities to sigma receptors (IC(50)=47-56 nM), the...
2.
Oshiro Y, Sakurai Y, Sato S, Kurahashi N, Tanaka T, Kikuchi T, et al.
J Med Chem
. 2000 Jan;
43(2):177-89.
PMID: 10649973
To develop a novel antidepressant drug with central nervous system-stimulating activity, we prepared a series of 1-[omega-(4-substituted phenyl-1-piperazinyl)alkyl]-3, 4-dihydro-2(1H)-quinolinone derivatives and examined their activities by their effects at 30 and...
3.
Oshiro Y, Sato S, Kurahashi N, Tanaka T, Kikuchi T, Tottori K, et al.
J Med Chem
. 1998 Mar;
41(5):658-67.
PMID: 9513593
To develop a novel antipsychotic agent which is an agonist of dopamine (DA) autoreceptors and an antagonist of postsynaptic DA receptors, a series of 7-[4-[4-(substituted phenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2 (1H)-quinolinones was synthesized and...
4.
Kikuchi T, Uwahodo Y, Tottori K, Nakai M, Morita S
Psychopharmacology (Berl)
. 1997 May;
131(2):108-14.
PMID: 9201797
It is known that beta-adrenoceptor antagonists are effective in the treatment of akathisia, one of the extrapyramidal side effects that occur during neuroleptic treatment. Neuroleptic-induced catalepsy, a model of neuroleptic-induced...
5.
Kikuchi T, Tottori K, Uwahodo Y, Hirose T, Miwa T, Oshiro Y, et al.
J Pharmacol Exp Ther
. 1995 Jul;
274(1):329-36.
PMID: 7616416
The effects of 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2 (1H)- quinolinone (OPC-14597), a derivative of the dopamine (DA) autoreceptor agonist 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on DA receptors were biochemically and behaviorally studied and compared with those of...
6.
Oshiro Y, Sakurai Y, Tanaka T, Kikuchi T, Hirose T, Tottori K
J Med Chem
. 1991 Jul;
34(7):2014-23.
PMID: 1676757
In a continuous search for a novel cerebroprotective drug with a central nervous system (CNS) stimulating activity, a series of 1-(acylamino)-7-hydroxyindan derivatives has been synthesized and tested for its dual...
7.
Oshiro Y, Sakurai Y, Tanaka T, Ueda H, Kikuchi T, Tottori K
J Med Chem
. 1991 Jul;
34(7):2004-13.
PMID: 1676756
To develop a novel cerebroprotective agent with central nervous system (CNS) stimulating activity, a series of 1-amino-7-hydroxyindan derivatives was synthesized, and their effects on the survival time of mice under...
8.
Tottori K, Takeuchi S
Nihon Sanka Fujinka Gakkai Zasshi
. 1981 Jan;
33(1):142-50.
PMID: 6164739
Carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), placental alkaline phosphatase (ALP4), human chorionic gonadotropin (HCG), human chorionic gonadotropin-beta-subunit (beta-HCG) and human placental lactogen (HPL) were simultaneously and serially determined in the sera...
9.
Sato Y, Tottori K, Higuchi A, Takeuchi S
Nihon Gan Chiryo Gakkai Shi
. 1979 Jun;
14(3):306-12.
PMID: 90106
No abstract available.