K Shimokata
Overview
Explore the profile of K Shimokata including associated specialties, affiliations and a list of published articles.
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Articles
293
Citations
2278
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Recent Articles
1.
Nozaki Y, Isobe K, Nakashima I, Shimokata K
Int J Oncol
. 2011 May;
2(6):1053-7.
PMID: 21573670
Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain...
2.
Shiraki A, Kume H, Oguma T, Makino Y, Ito S, Shimokata K, et al.
Clin Exp Allergy
. 2009 Jan;
39(2):236-45.
PMID: 19134015
Background: Isoprostanes are prostaglandin (PG)-like compounds synthesized by oxidative stress, not by cyclooxygenase, and increase in bronchoalveolar lavage fluid of patients with asthma. The airway inflammation implicated in this disease...
3.
Kobayashi M, Kume H, Oguma T, Makino Y, Ito Y, Shimokata K
Clin Exp Allergy
. 2007 Nov;
38(1):135-44.
PMID: 18028457
Background: Recent studies have revealed that in asthma, mast cells infiltrate to the smooth muscle layer and release tryptase, an enzymatic activator of protease-activated receptor 2 (PAR2). This phenomenon, mast...
4.
Oguma T, Ito S, Kondo M, Makino Y, Shimokata K, Honjo H, et al.
Clin Exp Allergy
. 2007 May;
37(6):893-900.
PMID: 17517103
Background: The release of adenosine triphosphate (ATP) from the airway epithelial cells during the inflammatory process is considered to play an important role in the pathophysiology of asthma and chronic...
5.
Taki F, Kume H, Kobayashi T, Ohta H, Aratake H, Shimokata K
Clin Exp Allergy
. 2007 Apr;
37(4):599-607.
PMID: 17430358
Background: A small GTPase, Rho, and its target molecule, Rho-kinase, play an important role in the cell functions, including contractility, chemotaxis, adhesion, and migration. It is generally considered that eosinophilic...
6.
Suzuki R, Hasegawa Y, Baba K, Saka H, Saito H, Taniguchi H, et al.
Br J Cancer
. 2006 May;
94(11):1599-603.
PMID: 16670714
The aim of this study was to evaluate the efficacy and tolerability of gefitinib ('IRESSA') in Japanese patients with previously untreated stage IV non-small-cell lung cancer (NSCLC). This was a...
7.
Oguma T, Kume H, Ito S, Takeda N, Honjo H, Kodama I, et al.
Clin Exp Allergy
. 2006 Jan;
36(2):183-91.
PMID: 16433855
Background: It is well known that beta-adrenoceptor agonists (beta-agonists) cause relaxation in airway smooth muscle mediated by a reduction in the concentration of intracellular Ca2+ ([Ca2+](i)). However, little is currently...
8.
Suzuki K, Yamamoto M, Hasegawa Y, Ando M, Shima K, Sako C, et al.
Lung Cancer
. 2004 Nov;
46(3):357-60.
PMID: 15541821
We evaluated the usefulness of double-dose (0.2 mmol/kg of gadoteridol) contrast-enhanced magnetic resonance imaging (C-E MRI) in detecting brain metastases of lung cancer. We prospectively enrolled 134 patients with lung...
9.
Kondo T, Ohno M, Shimokata K, Iino S, Inden Y, Murohara T, et al.
Heart
. 2003 Jul;
89(8):931-2.
PMID: 12860878
No abstract available.
10.
Ishikawa T, Kume H, Kondo M, Ito Y, Yamaki K, Shimokata K
Clin Exp Allergy
. 2003 Jun;
33(6):808-15.
PMID: 12801317
Background: Transforming growth factor-beta1 (TGF-beta 1) is generally considered to play an important role in the pathogenesis of chronic inflammation and fibrosis. Objective And Methods: This study was designed to...