K Ruscher
Overview
Explore the profile of K Ruscher including associated specialties, affiliations and a list of published articles.
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10
Citations
308
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Recent Articles
1.
Capela J, Ruscher K, Lautenschlager M, Freyer D, Dirnagl U, Gaio A, et al.
Neuroscience
. 2006 Mar;
139(3):1069-81.
PMID: 16504407
Studies on 3,4-methylenedioxymethamphetamine ("ecstasy")-induced neurotoxicity mainly focus on damage of serotonergic terminals. Less attention has been given to neuronal cell death produced by 3,4-methylenedioxymethamphetamine and other amphetamines in areas including...
2.
Weih M, Schmitt M, Gieche J, Harms C, Ruscher K, Dirnagl U, et al.
J Cereb Blood Flow Metab
. 2001 Aug;
21(9):1090-6.
PMID: 11524613
Oxidative injury contributes to cellular damage during and after cerebral ischemia. However, the downstream catabolic pathways of damaged cellular components in neurons are largely unknown. In the current study, the...
3.
Weih M, Prass K, Ruscher K, Trendelenburg G, Dirnagl U, Riepe M, et al.
Nervenarzt
. 2001 Apr;
72(4):255-60.
PMID: 11320860
A brief episode of ischemia renders the brain resistant against subsequent, longer ischemic events. This ischemic tolerance has been shown in numerous experimental models of cerebral ischemia. After global cerebral...
4.
Lautenschlager M, Onufriev M, Gulyaeva N, Harms C, Freyer D, Sehmsdorf U, et al.
Neuroscience
. 2000 May;
97(2):383-93.
PMID: 10799770
The involvement of nitric oxide in neurodegenerative processes still remains incompletely characterized. Although nitric oxide has been reported to be an important mediator in neuronal degeneration in different models of...
5.
Endres M, Meisel A, Biniszkiewicz D, Namura S, Prass K, Ruscher K, et al.
J Neurosci
. 2000 Apr;
20(9):3175-81.
PMID: 10777781
DNA methylation is important for controlling the profile of gene expression and is catalyzed by DNA methyltransferase (MTase), an enzyme that is abundant in brain. Because significant DNA damage and...
6.
Ruscher K, Reuter M, Kupper D, Trendelenburg G, Dirnagl U, Meisel A
J Biotechnol
. 2000 Mar;
78(2):163-70.
PMID: 10725539
Electrophoretic mobility shift assay (EMSA) or gel shift assay is one of the most powerful methods for studying protein-DNA interactions. Typically, 32P-labeled DNA probes containing the sequence bound by the...
7.
Wiegand F, Liao W, Busch C, Castell S, Knapp F, Lindauer U, et al.
J Cereb Blood Flow Metab
. 1999 Nov;
19(11):1229-37.
PMID: 10566969
The authors show that the inhibitor of the succinate dehydrogenase, 3-nitroproprionic acid (3-NPA), which in high doses and with chronic administration is a neurotoxin, can induce profound tolerance to focal...
8.
Weih M, Bergk A, Isaev N, Ruscher K, Megow D, Riepe M, et al.
Neurosci Lett
. 1999 Oct;
272(3):207-10.
PMID: 10505617
Sublethal ischemia leads to increased tolerance against subsequent ischemia. We investigated whether tolerance could also be elicited by mild respiratory-chain inhibition (chemical hypoxia) in a rat neuronal-cell enriched culture system....
9.
Ruscher K, Isaev N, Trendelenburg G, Weih M, Iurato L, Meisel A, et al.
Neurosci Lett
. 1998 Oct;
254(2):117-20.
PMID: 9779934
Hypoxia-inducible factor 1 (HIF-1) is a posttranscriptionally regulated transcription factor, controlling several hypoxia-inducible genes. Here we show a rapid and transient increase of HIF-1 DNA binding activity in a dose...
10.
Bruer U, Weih M, Isaev N, Meisel A, Ruscher K, Bergk A, et al.
FEBS Lett
. 1997 Sep;
414(1):117-21.
PMID: 9305743
Sublethal ischemia leads to increased tolerance against subsequent prolonged cerebral ischemia in vivo. In the present study we modeled preconditioning mechanisms in a neuronal-enriched culture. Damage was significantly reduced (up...