K R Valetdinova
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Explore the profile of K R Valetdinova including associated specialties, affiliations and a list of published articles.
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10
Citations
122
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Recent Articles
1.
Maretina M, Valetdinova K, Tsyganova N, Egorova A, Ovechkina V, Schioth H, et al.
Gene
. 2021 Dec;
811:146109.
PMID: 34871761
Spinal muscular atrophy is a progressive motor neuron disorder caused by deletions or point mutations in the SMN1 gene. It is not known why motor neurons are particularly sensitive to...
2.
Malakhova A, Grigoreva E, Pavlova S, Malankhanova T, Valetdinova K, Vyatkin Y, et al.
Stem Cell Res
. 2020 Aug;
48:101952.
PMID: 32805537
ICGi021-A and ICGi022-A iPSC lines were obtained by reprogramming PBMCs of two healthy women of the Siberian population using episomal non-integrating vectors expressing Yamanaka factors. iPSC lines expressed pluripotency markers,...
3.
Ovechkina V, Maretina M, Egorova A, Baranov V, Kiselev A, Zakian S, et al.
Stem Cell Res
. 2020 Aug;
48:101938.
PMID: 32795928
Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes...
4.
Valetdinova K, Maretina M, Vyatkin Y, Perepelkina M, Egorova A, Baranov V, et al.
Stem Cell Res
. 2020 Aug;
48:101941.
PMID: 32777771
Duchenne muscular dystrophy (DMD) is a severe and rapidly progressive hereditary muscular disease with X-linked recessive inheritance, occurring mainly in males. A complete loss of dystrophin resulted from out-of-frame deletion...
5.
Malakhova A, Grigoreva E, Malankhanova T, Pavlova S, Valetdinova K, Abramycheva N, et al.
Stem Cell Res
. 2020 Mar;
44:101743.
PMID: 32179492
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the HTT gene. HD patient-specific induced pluripotent stem cells (iPSCs) represent an excellent model for...
6.
Valetdinova K, Ovechkina V, Zakian S
Biochemistry (Mosc)
. 2019 Nov;
84(9):1074-1084.
PMID: 31693467
The CRISPR/Cas technology has a great potential in the treatment of many hereditary diseases. One of the prospective models for the CRISPR/Cas-mediated therapy is spinal muscular atrophy (SMA), a disease...
7.
Podgurskaya A, Tsvelaya V, Slotvitsky M, Dementyeva E, Valetdinova K, Agladze K
Cardiovasc Toxicol
. 2019 Jun;
19(6):518-528.
PMID: 31165980
Erythromycin is an antibiotic that prolongs the QT-interval and causes Torsade de Pointes (TdP) by blocking the rapid delayed rectifying potassium current (I) without affecting either the slow delayed rectifying...
8.
Valetdinova K, Maretina M, Kuranova M, Grigoreva E, Minina Y, Kizilova E, et al.
Stem Cell Res
. 2019 Jan;
34:101376.
PMID: 30660867
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by deletion or mutation in SMN1 gene. SMA human induced pluripotent stem cells (iPSCs) represent a useful and valid model for...
9.
Valetdinova K, Medvedev S, Zakian S
Acta Naturae
. 2015 May;
7(1):19-36.
PMID: 25926999
Over the past 30 years, many molecular genetic mechanisms underlying motor neuron diseases (MNDs) have been discovered and studied. Among these diseases, amyotrophic lateral sclerosis (ALS), which causes the progressive...
10.
Nemudryi A, Valetdinova K, Medvedev S, Zakian S
Acta Naturae
. 2014 Oct;
6(3):19-40.
PMID: 25349712
Precise studies of plant, animal and human genomes enable remarkable opportunities of obtained data application in biotechnology and medicine. However, knowing nucleotide sequences isn't enough for understanding of particular genomic...