K R Twigger
Overview
Explore the profile of K R Twigger including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
3
Citations
163
Followers
0
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Recent Articles
1.
Errington F, White C, Twigger K, Rose A, Scott K, Steele L, et al.
Gene Ther
. 2008 Apr;
15(18):1257-70.
PMID: 18401435
Reovirus is a promising unmodified double-stranded RNA (dsRNA) anti-cancer oncolytic virus, which is thought to specifically target cells with activated Ras. Although reovirus has been tested in a wide range...
2.
White C, Twigger K, Vidal L, de Bono J, Coffey M, Heinemann L, et al.
Gene Ther
. 2008 Mar;
15(12):911-20.
PMID: 18323793
There is an emerging realization from animal models that the immune response may have both detrimental and beneficial therapeutic effects during cancer virotherapy. However, there is a dearth of clinical...
3.
Escherichia coli nitroreductase plus CB1954 enhances the effect of radiotherapy in vitro and in vivo
White C, Menghistu T, Twigger K, Searle P, Bhide S, Vile R, et al.
Gene Ther
. 2007 Dec;
15(6):424-33.
PMID: 18079753
Escherichia coli nitroreductase (NTR) converts the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent that causes DNA crosslinks. In this study, the ability of NTR to enhance the combined effects...