K Peter Giese
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Explore the profile of K Peter Giese including associated specialties, affiliations and a list of published articles.
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63
Citations
1507
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Recent Articles
1.
Perez-Sisques L, Bhatt S, Matuleviciute R, Gileadi T, Kramar E, Graham A, et al.
J Neurosci
. 2024 Apr;
44(19).
PMID: 38575342
The histone lysine demethylase KDM5B is implicated in recessive intellectual disability disorders, and heterozygous, protein-truncating variants in are associated with reduced cognitive function in the population. The KDM5 family of...
2.
Using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data
Bahl E, Chatterjee S, Mukherjee U, Elsadany M, Vanrobaeys Y, Lin L, et al.
Nat Commun
. 2024 Jan;
15(1):779.
PMID: 38278804
Neuronal activity-dependent transcription directs molecular processes that regulate synaptic plasticity, brain circuit development, behavioral adaptation, and long-term memory. Single cell RNA-sequencing technologies (scRNAseq) are rapidly developing and allow for the...
3.
Peng X, Wellard N, Ghosh A, Troakes C, Giese K
Brain Res Bull
. 2023 Dec;
206:110849.
PMID: 38128786
In humans, the cytoplasmic FMR1 interacting protein (CYFIP) family consists of two members, namely CYFIP1 and CYFIP2. Both CYFIP1 and CYFIP2 function in the WAVE regulatory complex (WRC), which regulates...
4.
Martinez-Serra R, Alonso-Nanclares L, Cho K, Giese K
Brain Commun
. 2022 Jun;
4(2):fcac083.
PMID: 35652120
Alzheimer's disease is the leading cause of dementia and a growing worldwide problem, with its incidence expected to increase in the coming years. Since synapse loss is a major pathology...
5.
Chatterjee S, Bahl E, Mukherjee U, Walsh E, Shetty M, Yan A, et al.
Sci Adv
. 2022 Mar;
8(12):eabm6063.
PMID: 35319980
The mechanisms underlying memory loss associated with Alzheimer's disease and related dementias (ADRD) remain unclear, and no effective treatments exist. Fundamental studies have shown that a set of transcriptional regulatory...
6.
7.
Borczyk M, Radwanska K, Giese K
Brain Res Bull
. 2021 May;
173:28-36.
PMID: 33984429
Plasticity of glutamatergic synapses in the hippocampus is believed to underlie learning and memory processes. Surprisingly, very few studies report long-lasting structural changes of synapses induced by behavioral training. It...
8.
Gileadi T, Swamy A, Hore Z, Horswell S, Ellegood J, Mohan C, et al.
Environ Health Perspect
. 2021 May;
129(5):57002.
PMID: 33956508
Background: 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) is a persistent and toxic environmental pollutant. Gestational exposure to TCDD has been linked to cognitive and motor deficits, and increased incidence of autism spectrum disorder (ASD)...
9.
Caly A, Sliwinska M, Ziolkowska M, Lukasiewicz K, Pagano R, Dzik J, et al.
J Neurosci
. 2021 Jan;
41(11):2329-2343.
PMID: 33472821
Cognitive processes that require spatial information rely on synaptic plasticity in the dorsal CA1 area (dCA1) of the hippocampus. Since the function of the hippocampus is impaired in aged individuals,...
10.
Chatterjee S, Angelakos C, Bahl E, Hawk J, Gaine M, Poplawski S, et al.
BMC Biol
. 2020 Oct;
18(1):155.
PMID: 33121486
Background: CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands of genes....