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K Onozaki

Explore the profile of K Onozaki including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 116
Citations 744
Followers 0
Related Specialties
Allergy & Immunology
Biochemistry
Cell Biology
Top 10 Co-Authors
H Hayashi
T TAKII
T Hashimoto
T Chiba
Y Homma
K Matsushima
A Takeuchi
Y Takei
Y Oomoto
Y Fukutomi
Published In
Cell Immunol
J Interferon Cytokine Res
J Immunol
Biochem Biophys Res Commun
Glycoconj J
Affiliations
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Recent Articles
1.
Smad3 is acetylated by p300/CBP to regulate its transactivation activity
Inoue Y, Itoh Y, Abe K, Okamoto T, Daitoku H, Fukamizu A, et al.
Oncogene . 2006 Jul; 26(4):500-8. PMID: 16862174
Smad proteins are crucial for the intracellular signaling of transforming growth factor-beta (TGF-beta). Upon their receptor-induced activation, Smad proteins are phosphorylated and translocated to the nucleus to activate the transcription...
2.
Synthesis of a set of di- and tri-sulfated galabioses
Yoshida T, Chiba T, Yokochi T, Onozaki K, Sugiyama T, Nakashima I
Carbohydr Res . 2001 Oct; 335(3):167-80. PMID: 11578633
Among cell-adhesion molecules, L-selectin recognizes sulfated sLe(x) with relatively low affinity. Here, we aimed at artificial mimics by synthesizing a set of di- and tri-sulfated galabioses, which may surpass the...
3.
CHOP, a basic leucine zipper transcriptional factor, contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6
Hattori T, Itoh S, Hayashi H, Chiba T, TAKII T, Yoshizaki K, et al.
J Interferon Cytokine Res . 2001 Jun; 21(5):323-32. PMID: 11429163
Interleukin-1 (IL-1) inhibits the proliferation of A375 human melanoma cells. We have demonstrated previously that p38 mitrogen-activated protein kinase (MAPK) mediated the antiproliferative effect of IL-1 partially through the downregulation...
4.
Activation of two distinct anti-proliferative pathways, apoptosis and p38 MAP kinase-dependent cell cycle arrest, by tumor necrosis factor in human melanoma cell line A375
Hattori T, Hayashi H, Chiba T, Onozaki K
Eur Cytokine Netw . 2001 Jun; 12(2):244-52. PMID: 11399512
The proliferation of human melanoma cell line A375-6 cells is inhibited by several cytokines, including interleukin-1 (IL-1). A375-R8 cells, a subclone of A375-6, are resistant to IL-1-induced growth inhibition. The...
5.
Interleukin-1 or tumor necrosis factor-alpha augmented the cytotoxic effect of mycobacteria on human fibroblasts: application to evaluation of pathogenesis of clinical isolates of Mycobacterium tuberculosis and M. avium complex
TAKII T, Abe C, Tamura A, Ramayah S, Belisle J, Brennan P, et al.
J Interferon Cytokine Res . 2001 May; 21(3):187-96. PMID: 11331042
Mycobacteria-induced in vitro events reflecting human tuberculosis can contribute to the evaluation of the pathogenesis of Mycobacterium tuberculosis (MTB). In this study, we propose such an in vitro method based...
6.
Glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution
Sasayama S, Moriya K, Chiba T, Matsumura T, Hayashi H, Hayashi A, et al.
Glycoconj J . 2001 Apr; 17(6):353-9. PMID: 11294501
In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to...
7.
Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and TLR4 gene expression in murine liver and hepatocytes
Matsumura T, Ito A, TAKII T, Hayashi H, Onozaki K
J Interferon Cytokine Res . 2000 Oct; 20(10):915-21. PMID: 11054280
Toll-like receptor (TLR) 2 and TLR4 are members of the interleukin-1 receptor (IL-1R) family and transduce similar signals as IL-1R in response to bacteria and bacterial components. In this study,...
8.
Comparison of anti-tumor responses against TL positive lymphoma induced by skin grafting and dendritic cell immunization
Iwase S, Tsujimura K, MATSUDAIRA Y, Ozeki S, Onozaki K, Obata Y, et al.
Microbiol Immunol . 2000 Sep; 44(7):609-18. PMID: 10981835
When the skin of Tg.Con.3-1 transgenic mice expressing the TL (thymus leukemia) antigen in most tissues is grafted on syngeneic C3H mice, it is rejected, and a cytotoxic T cell...
9.
Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes
Watanabe S, Katagiri K, Onozaki K, Hata N, Misawa Y, Hamazaki T, et al.
Prostaglandins Leukot Essent Fatty Acids . 2000 Jun; 62(3):147-52. PMID: 10841036
Mice were fed a diet supplemented either with beef tallow (BT), BT plus ethyl eicosapentaenoate (EPA) or BT plus ethyl docosahexaenoate (DHA) for 9 weeks. EPA and DHA supplementation increased...
10.
In vitro biological activities of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid
Moriya K, Chiba T, Nabeshima S, Hayashi H, Onozaki K
Glycoconj J . 2000 May; 16(9):563-8. PMID: 10815993
In the previous study, N-acetylneuraminic acid (NANA) with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its biological activities,...