K M Derbyshire
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Explore the profile of K M Derbyshire including associated specialties, affiliations and a list of published articles.
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21
Citations
415
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Recent Articles
1.
Clark R, Lapierre P, Lasek-Nesselquist E, Gray T, Derbyshire K
mBio
. 2022 Mar;
13(2):e0021322.
PMID: 35297678
Mycobacteria mediate horizontal gene transfer (HGT) by a process called distributive conjugal transfer (DCT) that is mechanistically distinct from -mediated plasmid transfer. The transfer of multiple, independent donor chromosome segments...
2.
Judd J, Canestrari J, Clark R, Joseph A, Lapierre P, Lasek-Nesselquist E, et al.
mBio
. 2021 Mar;
12(2).
PMID: 33653882
Functional characterization of bacterial proteins lags far behind the identification of new protein families. This is especially true for bacterial species that are more difficult to grow and genetically manipulate...
3.
Tavakoli N, Derbyshire K
EMBO J
. 2001 Jun;
20(11):2923-30.
PMID: 11387225
The bacterial insertion sequence IS903 has the unusual ability to transpose both replicatively and non-replicatively. The majority of products are simple insertions, while co-integrates, the product of replicative transposition, occur...
4.
Hu W, Thompson W, Lawrence C, Derbyshire K
J Mol Biol
. 2001 Feb;
306(3):403-16.
PMID: 11178901
Like many transposons the bacterial insertion sequence IS903 was thought to insert randomly. However, using both genetic and statistical approaches, we have derived a target site for IS903 that is...
5.
Machowski E, McAdam R, Derbyshire K, Mizrahi V
Gene
. 2000 Aug;
253(1):67-75.
PMID: 10925203
The transposon Tn5367, which is a derivative of the mycobacterial insertion sequence IS1096, was modified by introducing novel genes to produce reporter transposons which can be used to generate transposon...
6.
Thomson V, Bhattacharjee M, Fine D, Derbyshire K, Figurski D
J Bacteriol
. 1999 Nov;
181(23):7298-307.
PMID: 10572134
Transposon mutagenesis in bacteria generally requires efficient delivery of a transposon suicide vector to allow the selection of relatively infrequent transposition events. We have developed an IS903-based transposon mutagenesis system...
7.
Griffin 4th T, Parsons L, Leschziner A, DeVost J, Derbyshire K, Grindley N
Nucleic Acids Res
. 1999 Sep;
27(19):3859-65.
PMID: 10481025
We have explored the potential of the Tn 552 in vitro transposition reaction as a genetic tool. The reaction is simple (requiring a single protein component), robust and efficient, readily...
8.
Tavakoli N, Derbyshire K
Mol Microbiol
. 1999 Mar;
31(4):1183-95.
PMID: 10096085
The inverted repeats (IRs) of the insertion element IS903 are composed of two functional regions. An inner region, consisting of basepairs 6-18, is the transposase binding site. The outer region...
9.
Parsons L, Jankowski C, Derbyshire K
Mol Microbiol
. 1998 Jun;
28(3):571-82.
PMID: 9632259
The genus Mycobacterium includes the major human pathogens Mycobacterium tuberculosis and Mycobacterium leprae. The development of rational drug treatments for the diseases caused by these and other mycobacteria requires the...
10.
Hu W, Derbyshire K
J Bacteriol
. 1998 Jun;
180(12):3039-48.
PMID: 9620951
We have examined the targeting preference of the bacterial insertion element IS903 by determining the sites of insertion of a large number of transposition events into the 55-kb conjugative plasmid...