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K Leenhouts

Explore the profile of K Leenhouts including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 700
Followers 0
Related Specialties
Microbiology
Allergy & Immunology
Molecular Biology
Top 10 Co-Authors
J Kok
G Venema
A Bolhuis
M L van Roosmalen
G Buist
A Huckriede
G M Hooykaas-van Slogteren
R A Schilperoort
V Saluja
G J Wullems
Published In
Vaccine
Appl Environ Microbiol
Mol Gen Genet
Plant Mol Biol
Antonie Van Leeuwenhoek
Affiliations
Soon will be listed here.
Recent Articles
1.
Heterologous Processing and Export of the Bacteriocins Pediocin PA-1 and Lactococcin A in Lactococcus Lactis: A Study with Leader Exchange
Chikindas M, Emond E, Haandrikman A, Kok J, Leenhouts K, Pandian S, et al.
Probiotics Antimicrob Proteins . 2016 Jan; 2(2):66-76. PMID: 26781115
The bacteriocins pediocin PA-1 and lactococcin A are synthesized as precursors carrying N-terminal extensions with a conserved cleavage site preceded by two glycine residues in positions -2 and -1. Each...
2.
Inactivated influenza vaccine adjuvanted with bacterium-like particles induce systemic and mucosal influenza A virus specific T-cell and B-cell responses after nasal administration in a TLR2 dependent fashion
Keijzer C, Haijema B, Meijerhof T, Voorn P, de Haan A, Leenhouts K, et al.
Vaccine . 2014 Mar; 32(24):2904-10. PMID: 24598720
Background: Nasal vaccination is considered to be a promising alternative for parenteral vaccination against influenza virus as it is non-invasive and offers the opportunity to elicit strong antigen-specific responses both...
3.
Clones from a shooty tobacco crown gall tumor II: irregular T-DNA structures and organization, T-DNA methylation and conditional expression of opine genes
Peerbolte R, Leenhouts K, Hooykaas-van Slogteren G, Wullems G, Schilperoort R
Plant Mol Biol . 2013 Dec; 7(4):285-99. PMID: 24302370
Transformed clones from a shooty tobacco crown gall tumor, induced byAgrobacterium tumefaciens strain LBA1501, having the auxin locus of the TL-region inactivated by a Tn1831 insertion, were investigated for their...
4.
Clones from a shooty tobacco crown gall tumor I: deletions, rearrangements and amplifications resulting in irregular T-DNA structures and organizations
Peerbolte R, Leenhouts K, Hooykaas-van Slogteren G, Hoge J, Wullems G, Schilperoort R
Plant Mol Biol . 2013 Dec; 7(4):265-84. PMID: 24302369
Transformed clones from a shooty tobacco crown gall tumor, induced byAgrobacterium tumefaciens strain LBA1501, having a Tn1831 insertion in the auxin locus, were investigated for their T-DNA structure and expression....
5.
Influenza antigen-sparing by immune stimulation with Gram-positive enhancer matrix (GEM) particles
Saluja V, Visser M, Ter Veer W, van Roosmalen M, Leenhouts K, Hinrichs W, et al.
Vaccine . 2010 Oct; 28(50):7963-9. PMID: 20946860
Gram-positive enhancer matrix (GEM) particles, produced from non-genetically modified Lactococcus lactis bacteria have an inherent immunostimulatory activity. It was investigated whether co-administration of GEM particles can reduce the amount of...
6.
Gastro-intestinal delivery of influenza subunit vaccine formulation adjuvanted with Gram-positive enhancer matrix (GEM) particles
Saluja V, Visser M, van Roosmalen M, Leenhouts K, Huckriede A, Hinrichs W, et al.
Eur J Pharm Biopharm . 2010 Aug; 76(3):470-4. PMID: 20719246
In this study, a liquid formulation of influenza subunit vaccine admixed with Gram-positive enhancer matrix (GEM) particles as adjuvant was delivered to upper and lower parts of intestinal tract. The...
7.
Neonatal mucosal immunization with a non-living, non-genetically modified Lactococcus lactis vaccine carrier induces systemic and local Th1-type immunity and protects against lethal bacterial infection
Ramirez K, Ditamo Y, Rodriguez L, Picking W, van Roosmalen M, Leenhouts K, et al.
Mucosal Immunol . 2009 Nov; 3(2):159-71. PMID: 19924118
Safe and effective immunization of newborns and infants can significantly reduce childhood mortality, yet conventional vaccines have been largely unsuccessful in stimulating the neonatal immune system. We explored the capacity...
8.
Immunogenicity of a malaria parasite antigen displayed by Lactococcus lactis in oral immunisations
Ramasamy R, Yasawardena S, Zomer A, Venema G, Kok J, Leenhouts K
Vaccine . 2006 Mar; 24(18):3900-8. PMID: 16545511
A putative protective protein from Plasmodium falciparum merozoites, MSA2, was expressed in two different ways on the cell surface of the Gram-positive food-grade bacterium, Lactococcus lactis. The first display format...
9.
Anchoring of proteins to lactic acid bacteria
Leenhouts K, Buist G, Kok J
Antonie Van Leeuwenhoek . 1999 Oct; 76(1-4):367-76. PMID: 10532392
The anchoring of proteins to the cell surface of lactic acid bacteria (LAB) using genetic techniques is an exciting and emerging research area that holds great promise for a wide...
10.
Cloning, expression, and chromosomal stabilization of the Propionibacterium shermanii proline iminopeptidase gene (pip) for food-grade application in Lactococcus lactis
Leenhouts K, Bolhuis A, Boot J, Deutz I, Toonen M, Venema G, et al.
Appl Environ Microbiol . 1998 Dec; 64(12):4736-42. PMID: 9835556
Proline iminopeptidase produced by Propionibacterium shermanii plays an essential role in the flavor development of Swiss-type cheeses. The enzyme (Pip) was purified and characterized, and the gene (pip) was cloned...