K Krishna Sharma
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Explore the profile of K Krishna Sharma including associated specialties, affiliations and a list of published articles.
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40
Citations
609
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Recent Articles
1.
Tender T, Rahangdale R, Balireddy S, Nampoothiri M, Sharma K, Raghu Chandrashekar H
Med Oncol
. 2021 Apr;
38(5):52.
PMID: 33796975
Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of cancer treatment which involves sensory and motor nerve dysfunction. Severe CIPN has been reported in around 5% of patients...
2.
Daszynski D, Santhoshkumar P, Phadte A, Sharma K, Zhong H, Lou M, et al.
Sci Rep
. 2019 Jun;
9(1):8459.
PMID: 31186457
The paradigm that cataracts are irreversible and that vision from cataracts can only be restored through surgery has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol...
3.
Raju M, Santhoshkumar P, Sharma K
Adv Biosyst
. 2018 Oct;
2(1).
PMID: 30271873
Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study we employed a cell penetrating peptide (CPP),...
4.
Phadte A, Santhoshkumar P, Sharma K
Exp Eye Res
. 2018 May;
174:185-195.
PMID: 29782825
Several mutations associated with congenital cataracts in human beings target conserved arginine residues in αA-crystallin. The N-terminal region of αA-crystallin is a "mutational hotspot," with multiple cataract-related mutations reported in...
5.
Phadte A, Santhoshkumar P, Sharma K
Mol Vis
. 2018 May;
24:297-304.
PMID: 29706763
Purpose: The G98R mutant of αA-crystallin is associated with the development of presenile cataracts. In vitro, the recombinant mutant protein exhibits altered structural and functional characteristics, along with the propensity...
6.
Raju M, Santhoshkumar P, Sharma K
Aging Dis
. 2017 Feb;
8(1):57-70.
PMID: 28203481
In previous studies, we reported the presence of a large number of low-molecular-weight (LMW) peptides in aged and cataract human lens tissues. Among the LMW peptides, a peptide derived from...
7.
8.
Raju M, Santhoshkumar P, Sharma K
Biochim Biophys Acta
. 2015 Jul;
1860(1 Pt B):246-51.
PMID: 26141743
Background: The demonstration of chaperone-like activity in peptides (mini-chaperones) derived from α-crystallin's chaperone region has generated significant interest in exploring the therapeutic potential of peptide chaperones in diseases of protein...
9.
Raju M, Mooney B, Thakkar K, Giblin F, Schey K, Sharma K
Exp Eye Res
. 2015 Feb;
132:151-60.
PMID: 25639202
Earlier we reported that low molecular weight (LMW) peptides accumulate in aging human lens tissue and that among the LMW peptides, the chaperone inhibitor peptide αA66-80, derived from α-crystallin protein,...
10.
Xie L, Santhoshkumar P, Reneker L, Sharma K
Invest Ophthalmol Vis Sci
. 2014 Jul;
55(8):4731-40.
PMID: 24994865
Purpose: Posterior capsule opacification (PCO) after cataract surgery is due in part to proliferation of the adhering lens epithelial cells and transdifferentiation into mesenchymal cells. The histone deacetylase (HDAC) inhibitors,...