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K C Brennan

Explore the profile of K C Brennan including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Carlson A, Davis H, Jones T, Brennan K, Torbey M, Ahmadian R, et al.
Transl Stroke Res . 2022 Apr; 14(2):160-173. PMID: 35364802
Touch and other types of patient stimulation are necessary in critical care and generally presumed to be beneficial. Recent pre-clinical studies as well as randomized trials assessing early mobilization have...
12.
Andrew R, Hartings J, Ayata C, Brennan K, Dawson-Scully K, Farkas E, et al.
Neurocrit Care . 2022 Mar; 37(Suppl 1):83-101. PMID: 35257321
Background: When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their...
13.
Andrew R, Farkas E, Hartings J, Brennan K, Herreras O, Muller M, et al.
Neurocrit Care . 2022 Feb; 37(Suppl 1):11-30. PMID: 35194729
Background: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue,...
14.
Suryavanshi P, Reinhart K, Shuttleworth C, Brennan K
J Neurosci . 2021 Dec; 42(11):2371-2383. PMID: 34857650
Spreading depolarizations (SDs) of gray matter occur in the brain in different pathologic conditions, and cause varying degrees of tissue damage depending on the extent of metabolic burden on the...
15.
Reinhart K, Humphrey A, Brennan K, Carlson A, Shuttleworth C
Neurocrit Care . 2021 Oct; 35(Suppl 2):135-145. PMID: 34657268
Background: Spreading depolarization (SD) has been identified as a key mediator of secondary lesion progression after acute brain injuries, and clinical studies are beginning to pharmacologically target SDs. Although initial...
16.
Ishii R, Schwedt T, Trivedi M, Dumkrieger G, Cortez M, Brennan K, et al.
J Headache Pain . 2021 Jul; 22(1):80. PMID: 34294026
Background: Headache is one of the most common symptoms after concussion, and mild traumatic brain injury (mTBI) is a risk factor for chronic migraine (CM). However, there remains a paucity...
17.
Cortez M, Theriot J, Rea N, Gowen F, Brennan K
Cephalalgia Rep . 2021 May; 2. PMID: 34046553
Background: Surface imaging is a promising, noninvasive approach to assess regional perfusion in craniovascular disorders such as migraine. Methods: We used optical imaging to examine differences in facial blood volume...
18.
Cortez M, Millsap L, Rea N, Sciarretta C, Brennan K
Cephalalgia . 2021 Apr; 41(10):1089-1099. PMID: 33910382
Objective: To assess photophobia and allodynia in subjects with post-traumatic headache and examine how these sensory hypersensitivities associate with clinical measures of disease burden. Background: Post-traumatic headache is the most...
19.
Parker P, Suryavanshi P, Melone M, Sawant-Pokam P, Reinhart K, Kaufmann D, et al.
Neuron . 2020 Dec; 109(4):611-628.e8. PMID: 33321071
Migraine with aura is a common but poorly understood sensory circuit disorder. Monogenic models allow an opportunity to investigate its mechanisms, including spreading depolarization (SD), the phenomenon underlying migraine aura....
20.
Cortez M, Millsap L, Brennan K
Clin Auton Res . 2020 Nov; 31(2):263-271. PMID: 33174112
Purpose: Up to 90% of patients with postural tachycardia syndrome (PoTS) report headaches, and comorbid migraine headaches are common. Given this, pathophysiological interaction is possible, which may reveal key aspects...