K Brebner
Overview
Explore the profile of K Brebner including associated specialties, affiliations and a list of published articles.
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11
Citations
377
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Recent Articles
1.
Freeman W, Brebner K, Amara S, Reed M, Pohl J, Phillips A
Pharmacogenomics J
. 2005 Apr;
5(3):203-14.
PMID: 15852055
In the rat, continuous access to d-amphetamine (d-AMPH) leads to lengthy bouts of self-administration, voluntary abstinence, and relapse to self-administration. Previous studies have revealed that the progression from psychostimulant self-administration...
2.
Morgan D, Brebner K, Lynch W, Roberts D
Behav Pharmacol
. 2002 Oct;
13(5-6):389-96.
PMID: 12394415
In humans, the progression to cocaine addiction presumably involves increases in the effectiveness of cocaine to function as a reinforcer. Here we use breakpoints assessed using the progressive ratio (PR)...
3.
Freeman W, Brebner K, Lynch W, Robertson D, Roberts D, Vrana K
Neuroscience
. 2001 Dec;
108(3):371-80.
PMID: 11738252
Chronic cocaine use is known to elicit changes in the pattern of gene expression within the brain. The hippocampus plays a critical role in learning and memory and may also...
4.
Brebner K, Phelan R, Roberts D
Psychopharmacology (Berl)
. 2001 Feb;
148(3):314-21.
PMID: 10755745
Rationale: Recent reports have indicated that the gamma-aminobutyric acid (GABA)B agonist baclofen attenuates the reinforcing effects of cocaine. Objectives: To further evaluate the effect of baclofen on cocaine self-administration under...
5.
Brebner K, Phelan R, Roberts D
Pharmacol Biochem Behav
. 2000 Sep;
66(4):857-62.
PMID: 10973526
The effect of microinjections of baclofen into the ventral tegmental area (VTA), nucleus accumbens, or striatum on cocaine self-administration reinforced on a progressive ratio schedule was investigated. Intra-VTA baclofen produced...
6.
Roberts D, Brebner K
Ann N Y Acad Sci
. 2000 Jul;
909:145-58.
PMID: 10911928
Recent experiments suggest that GABA compounds produce a clinically relevant modulation of cocaine reinforcement. This review summarizes the results of a number of studies that examined the effect of the...
7.
Brebner K, Hayley S, Zacharko R, Merali Z, Anisman H
Neuropsychopharmacology
. 2000 May;
22(6):566-80.
PMID: 10788757
The proinflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) influence neuroendocrine activity, promote central neurotransmitter alterations, and induce a constellation of symptoms collectively referred to as sickness behaviors....
8.
Brebner K, Froestl W, Andrews M, Phelan R, Roberts D
Neuropharmacology
. 1999 Dec;
38(11):1797-804.
PMID: 10587095
Previous self-administration experiments have shown that baclofen, the prototypical GABA(B) agonist, produces an apparent attenuation in the reinforcing effects of cocaine in rats. The present experiments examined the effects of...
9.
Hayley S, Brebner K, Lacosta S, Merali Z, Anisman H
J Neurosci
. 1999 Jun;
19(13):5654-65.
PMID: 10377371
Consistent with the proposition that cytokines act as immunotransmitters between the immune system and the brain, systemic administration of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha; 1.0-4.0 microg) induced mild...
10.
Vandenplas M, Vandenplas S, Brebner K, Bester A, Boyd C
Toxicon
. 1985 Jan;
23(2):289-305.
PMID: 4024139
Total polyadenylated messenger RNA was prepared from the milked venom glands of the South African puff adder (Bitis arietans) and translated in an in vitro translation system. The products of...