K A Sharp
Overview
Explore the profile of K A Sharp including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
2888
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Recent Articles
1.
Ward P, Cross J, Lu C, Weigert O, Abel-Wahab O, Levine R, et al.
Oncogene
. 2011 Oct;
31(19):2491-8.
PMID: 21996744
Mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) or its mitochondrial homolog IDH2 can lead to R(-)-2-hydroxyglutarate (2HG) production. To date, mutations in three active site arginine residues, IDH1 R132, IDH2...
2.
Sharp K, Brooks D
Biophys J
. 2009 May;
47(4):563-6.
PMID: 19431592
A numerical method for determining the electrophoretic mobility of a polyelectrolyte-coated particle is presented. The particle surface is modeled as having a permeable layer of polyelectrolyte molecules anchored to its...
3.
Madan B, Sharp K
Biophys J
. 2001 Sep;
81(4):1881-7.
PMID: 11566762
The heat capacities of hydration (dCp) of the five nucleic acid bases A, G, C, T, and U, the sugars ribose and deoxyribose, and the phosphate backbone were determined using...
4.
Chin K, Sharp K, Honig B, Pyle A
Nat Struct Biol
. 1999 Dec;
6(11):1055-61.
PMID: 10542099
Solutions to the nonlinear Poisson-Boltzmann equation were used to obtain the electrostatic potentials of RNA molecules that have known three-dimensional structures. The results are described in terms of isopotential contours...
5.
Kuntz I, Chen K, Sharp K, Kollman P
Proc Natl Acad Sci U S A
. 1999 Sep;
96(18):9997-10002.
PMID: 10468550
We explore the question of what are the best ligands for macromolecular targets. A survey of experimental data on a large number of the strongest-binding ligands indicates that the free...
6.
Exploration of the structural features defining the conduction properties of a synthetic ion channel
Dieckmann G, Lear J, Zhong Q, Klein M, Degrado W, Sharp K
Biophys J
. 1999 Feb;
76(2):618-30.
PMID: 9929468
The finite-difference Poisson-Boltzmann methodology was applied to a series of parallel, alpha-helical bundle models of the designed ion channel peptide Ac-(LSSLLSL)3-CONH2. This method is able to fully describe the current-voltage...
7.
Sharp K
Proteins
. 1998 Sep;
33(1):39-48.
PMID: 9741843
The change in free energy of binding of hen egg white lysozyme (HEL) to the antibody HyHel-10 arising from ten point mutations in HEL (D101K, D101G, K96M, K97D, K97G, K97G,...
8.
Dieckmann G, McRorie D, Lear J, Sharp K, Degrado W, Pecoraro V
J Mol Biol
. 1998 Jul;
280(5):897-912.
PMID: 9671558
To define the delicate interplay between metal chelation, protein folding and function in metalloproteins, a family of de novo-designed peptides was synthesized that self-assemble in aqueous solution to form two...
9.
LaBerge M, Sharp K, Vanderkooi J
Biophys Chem
. 1998 May;
71(1):9-20.
PMID: 9591357
The FTIR spectra of the asymmetric carboxylate absorption region of three c-type cytochromes--namely horse heart, yeast and bonito cytochromes c--as well as continuum electrostatic calculations performed on their respective protein...
10.
Sharp K
Biophys J
. 1998 Mar;
74(3):1241-50.
PMID: 9512022
A description is given of a method to calculate the electron transfer reorganization energy (lambda) in proteins using the linear or nonlinear Poisson-Boltzmann (PB) equation. Finite difference solutions to the...