Justin R Piro
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Explore the profile of Justin R Piro including associated specialties, affiliations and a list of published articles.
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16
Citations
583
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Recent Articles
1.
Arakawa R, Takano A, Nag S, Jia Z, Amini N, Maresca K, et al.
EJNMMI Res
. 2022 Mar;
12(1):13.
PMID: 35244788
Background: Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [C]PF-06809247 into a...
2.
Biber K, Bhattacharya A, Campbell B, Piro J, Rohe M, Staal R, et al.
Front Pharmacol
. 2019 Sep;
10:840.
PMID: 31507408
Alzheimer's disease (AD) is a large and increasing unmet medical need with no disease-modifying treatment currently available. Genetic evidence from genome-wide association studies (GWASs) and gene network analysis has clearly...
3.
Zhang L, Butler C, Maresca K, Takano A, Nag S, Jia Z, et al.
J Med Chem
. 2019 Sep;
62(18):8532-8543.
PMID: 31483137
Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of endocannabinoid signaling. Preclinically, inhibition of MAGL is known to provide...
4.
Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Piro J, Suidan G, Quan J, Pi Y, ONeill S, Ilardi M, et al.
J Neuroinflammation
. 2018 May;
15(1):142.
PMID: 29759062
Background: Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells,...
5.
McAllister L, Butler C, Mente S, ONeil S, Fonseca K, Piro J, et al.
J Med Chem
. 2018 Mar;
61(7):3008-3026.
PMID: 29498843
Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (CNS). Herein we report...
6.
Terrone G, Pauletti A, Salamone A, Rizzi M, Villa B, Porcu L, et al.
Epilepsia
. 2017 Nov;
59(1):79-91.
PMID: 29171003
Objective: Status epilepticus (SE) is a life-threatening and commonly drug-refractory condition. Novel therapies are needed to rapidly terminate seizures to prevent mortality and morbidity. Monoacylglycerol lipase (MAGL) is the key...
7.
Butler C, Beck E, Harris A, Huang Z, McAllister L, Am Ende C, et al.
J Med Chem
. 2017 Nov;
60(23):9860-9873.
PMID: 29148769
Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the conversion of 2-AG to arachidonic acid (AA), a precursor...
8.
Piro J, Benjamin D, Duerr J, Pi Y, Gonzales C, Wood K, et al.
Cell Rep
. 2012 Jul;
1(6):617-23.
PMID: 22813736
Although inflammation in the brain is meant as a defense mechanism against neurotoxic stimuli, increasing evidence suggests that uncontrolled, chronic, and persistent inflammation contributes to neurodegeneration. Most neurodegenerative diseases have...
9.
Deleault N, Walsh D, Piro J, Wang F, Wang X, Ma J, et al.
Proc Natl Acad Sci U S A
. 2012 Jun;
109(28):E1938-46.
PMID: 22711839
Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in...
10.
Deleault N, Piro J, Walsh D, Wang F, Ma J, Geoghegan J, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(22):8546-51.
PMID: 22586108
Infectious prions containing the pathogenic conformer of the mammalian prion protein (PrP(Sc)) can be produced de novo from a mixture of the normal conformer (PrP(C)) with RNA and lipid molecules....