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Justin C Boucher

Explore the profile of Justin C Boucher including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 214
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Recent Articles
11.
Boucher J, Li G, Kotani H, Cabral M, Morrissey D, Lee S, et al.
Cancer Immunol Res . 2020 Nov; 9(1):62-74. PMID: 33188139
An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others...
12.
Shrestha B, Zhang Y, Yu B, Li G, Boucher J, Beatty N, et al.
J Immunother . 2019 Dec; 43(3):79-88. PMID: 31834208
Adoptive cell therapy with ex vivo expanded tumor infiltrating lymphocytes or gene engineering T cells expressing chimeric antigen receptors (CAR) is a promising treatment for cancer patients. This production utilizes...
13.
Li G, Boucher J, Kotani H, Park K, Zhang Y, Shrestha B, et al.
JCI Insight . 2018 Sep; 3(18). PMID: 30232281
Chimeric antigen receptors (CARs) have an antigen-binding domain fused to transmembrane, costimulatory, and CD3ζ domains. Two CARs with regulatory approval include a CD28 or 4-1BB costimulatory domain. While both CARs...
14.
Bahnan W, Boucher J, Gayle P, Shrestha N, Rosen M, Aktas B, et al.
Infect Immun . 2018 Jan; 86(3). PMID: 29311243
The host employs both cell-autonomous and system-level responses to limit pathogen replication in the initial stages of infection. Previously, we reported that the eukaryotic initiation factor 2α (eIF2α) kinases heme-regulated...
15.
Khan W, Wright J, Kleiman E, Boucher J, Castro I, Clark E
Immunol Res . 2013 Dec; 57(1-3):335-53. PMID: 24293007
B-lymphocytes are integral to host defense against microbial pathogens and are associated with many autoimmune diseases. The B-cell receptor implements B-cell self-tolerance based on the antigen specificity, and B-cell-activating factor...