Junsuke Igarashi
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Explore the profile of Junsuke Igarashi including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
606
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Recent Articles
1.
Nishikido T, Oyama J, Shiraki A, Tsukamoto I, Igarashi J, Node K
Sci Rep
. 2019 Feb;
9(1):2533.
PMID: 30796271
2-Cl-C.OXT-A (COA-Cl) is a novel nucleic acid analogue that promotes tube-forming activity of human umbilical vein endothelial cells (HUVEC) through vascular endothelial growth factor (VEGF). The development of coronary collateral...
2.
Sakakibara N, Igarashi J, Takata M, Konishi R, Kato Y, Tsukamoto I
Chem Pharm Bull (Tokyo)
. 2017 May;
65(5):504-510.
PMID: 28458372
Five novel nucleoside analogs with mono or bis-hydroxymethylated cyclopropane rings at the N-position of the 2-chloroadenine moiety (2-chloro-carbocyclic oxetanocin A [COA-Cl] analog) were synthesized and evaluated using human umbilical vein...
3.
Hasan A, Ohmori K, Hashimoto T, Kamitori K, Yamaguchi F, Noma T, et al.
Biochem Biophys Res Commun
. 2017 Mar;
486(1):76-82.
PMID: 28263744
How nutritional excess leads to inflammatory responses in metabolic syndrome is not well characterized. Here, we evaluated the effects of ω-3 polyunsaturated fatty acid specific G-protein coupled receptor 120 (GPR120)...
4.
Hasan A, Ohmori K, Hashimoto T, Kamitori K, Yamaguchi F, Konishi K, et al.
Biogerontology
. 2016 Oct;
18(1):55-68.
PMID: 27734200
Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore,...
5.
Igarashi J, Okamoto R, Yamashita T, Hashimoto T, Karita S, Nakai K, et al.
Physiol Rep
. 2016 Apr;
4(6).
PMID: 27033444
We previously demonstrated a potent angiogenic effect of a newly developed adenosine-like agent namedCOA-Cl.COA-Cl exerted tube forming activity in human umbilical vein endothelial cells in the presence of normal human...
6.
Sakakibara N, Igarashi J, Takata M, Demizu Y, Misawa T, Kurihara M, et al.
Chem Pharm Bull (Tokyo)
. 2015 Sep;
63(9):701-9.
PMID: 26329863
Six novel carbocyclic oxetanocin A analogs (2-chloro-C.OXT-A; COA-Cl) with various hydroxymethylated or spiro-conjugated cyclobutane rings at the N(9)-position of the 2-chloropurine moiety were synthesized and evaluated using human umbilical vein...
7.
Hasan A, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, et al.
Mol Cell Endocrinol
. 2015 Feb;
406:10-8.
PMID: 25697344
Vascular endothelial growth factor-A (VEGF-A) released from adipocytes promotes angiogenesis; and thereby ameliorates the local hypoxia-induced adipose inflammation and insulin resistance. Here, we newly found that eicosapentaenoic acid (EPA) upregulated...
8.
Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, et al.
Pharmacol Res Perspect
. 2014 Dec;
2(5):e00068.
PMID: 25505610
COA-Cl (2Cl-C.OXT-A) is a recently developed adenosine-like nucleic acid analog that promotes angiogenesis via the mitogen-activated protein (MAP) kinases ERK1/2. Endothelial S1P1 receptor plays indispensable roles in developmental angiogenesis. In...
9.
Hashimoto T, Igarashi J, Hasan A, Ohmori K, Kohno M, Nagai Y, et al.
PLoS One
. 2013 Nov;
8(11):e79724.
PMID: 24223187
The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the metabolic effects of long-term treatment with mifepristone have...
10.
Igarashi J, Hashimoto T, Shoji K, Yoneda K, Tsukamoto I, Moriue T, et al.
Am J Physiol Cell Physiol
. 2013 Feb;
304(8):C790-800.
PMID: 23426970
Steroids exert direct actions on cardiovascular cells, although underlying molecular mechanisms remain incompletely understood. We examined if steroids modulate abundance of caveolin-1, a regulatory protein of cell-surface receptor pathways that...