Junsei Mimura
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Explore the profile of Junsei Mimura including associated specialties, affiliations and a list of published articles.
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54
Citations
2417
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Recent Articles
1.
Tatara Y, Kasai S, Kokubu D, Tsujita T, Mimura J, Itoh K
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38474243
GCN1 is recognized as a factor that is essential for the activation of GCN2, which is a sensor of amino acid starvation. This function is evolutionarily conserved from yeast to...
2.
Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler M, et al.
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955572
Sulforaphane (SFN) is a potent activator of the transcriptional factor, Nuclear Factor Erythroid 2 (NF-E2)-Related factor 2 (NRF2). SFN and its precursor, glucoraphanin (sulforaphane glucosinolate, SGS), have been shown to...
3.
Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, et al.
Int J Mol Sci
. 2022 Mar;
23(6).
PMID: 35328622
GCN1 is an evolutionarily-conserved ribosome-binding protein that mediates the amino acid starvation response as well as the ribotoxic stress response. We previously demonstrated that mutant mice lacking the GCN2-binding domain...
4.
Engler M, Mimura J, Yamazaki S, Itoh K
FEBS Open Bio
. 2020 Oct;
10(12):2771-2779.
PMID: 33108704
Jun dimerization protein 2 (JDP2) is a bZip-type transcription factor, which acts as a repressor or activator of several cellular processes, including cell differentiation and chromatin remodeling. Previously, we found...
5.
Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, et al.
PLoS One
. 2020 Aug;
15(8):e0236834.
PMID: 32780748
Purpose: Pulse wave velocity (PWV), an indicator of vascular stiffness, increases with age and is increasingly recognized as an independent risk factor for cardiovascular disease (CVD). Although many mechanical and...
6.
Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, et al.
PLoS Genet
. 2020 Apr;
16(4):e1008693.
PMID: 32324833
Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α) restores homeostasis...
7.
Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K
Biomolecules
. 2020 Feb;
10(2).
PMID: 32079324
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in...
8.
Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, et al.
Int J Mol Sci
. 2019 Apr;
20(7).
PMID: 30959808
Carnosic acid (CA) is a phytochemical found in some dietary herbs, such as L., and possesses antioxidative and anti-microbial properties. We previously demonstrated that CA functions as an activator of...
9.
Suto A, Kudo D, Yoshida E, Nagase H, Suto S, Mimura J, et al.
Pancreas
. 2018 Dec;
48(2):292-298.
PMID: 30589828
Objectives: Desmoplastic changes of extracellular matrix (ECM) containing large amounts of hyaluronan (HA) are of interest in chemo- and immunoresistance of pancreatic ductal adenocarcinoma (PDAC). The goal of this study...
10.
Kasai S, Mimura J, Ozaki T, Itoh K
Front Vet Sci
. 2018 Oct;
5:242.
PMID: 30364139
Iron has played an important role in energy production since the beginning of life, as iron-catalyzed redox reactions are required for energy production. Oxygen, a highly efficient electron acceptor with...