Junchun Chen
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Explore the profile of Junchun Chen including associated specialties, affiliations and a list of published articles.
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24
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81
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Recent Articles
1.
Qiu H, Jin H, Miao J, Li H, Chen J, Yang X, et al.
J Bone Miner Res
. 2025 Mar;
PMID: 40073838
Bone undergoes life-long remodelling, in which disorders of bone remodelling could occur in many pathological conditions including osteoporosis. Understanding the cellular metabolism of osteoclasts is key to developing new treatments...
2.
Wang J, Dong W, Song Q, Zhang S, Li M, Chen J, et al.
J Hazard Mater
. 2025 Jan;
488:137174.
PMID: 39879777
Nitrate pollution poses severe risks to aquatic ecosystems and human health. The electrocatalytic nitrate reduction reaction (NITRR) offers a promising environmental and economic solution for nitrate pollution treatment and nitrogen...
3.
Jin H, Rawlins J, Chen Y, Zheng X, Charlesworth O, Chen J, et al.
J Cell Physiol
. 2025 Jan;
240(1):e31500.
PMID: 39757951
Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined...
4.
Wang Z, Deng W, Tang K, Zhou Y, Chen J, Wang B, et al.
Biochem Pharmacol
. 2024 Nov;
231:116673.
PMID: 39613114
Osteoporosis is characterized by excessive osteoclast activity leading to bone loss, decreased bone mineral density, and increased susceptibility to fractures. Through in vivo/vitro experiments, along with network pharmacology analysis, we...
5.
Huang J, Song D, Xu M, Gan K, Wang C, Chen L, et al.
Phytother Res
. 2024 Aug;
38(9):4650-4666.
PMID: 39098645
Inflammatory osteolysis is often caused by the excessive activation of osteoclasts stimulated by bacterial products such as lipopolysaccharide. The natural flavonoid trifolirhizin (TRI) has anti-inflammatory properties; however, its function in...
6.
Gan K, Lian H, Yang T, Huang J, Chen J, Su Y, et al.
Cell Death Discov
. 2024 Feb;
10(1):86.
PMID: 38368392
The key target for treating inflammatory osteolysis is osteoclasts. In an inflammatory environment, osteoclast differentiation increases, and bone resorption is enhanced. Periplogenin (Ppg) is a traditional Chinese medicine. It has...
7.
Li H, Deng W, Yang J, Lin Y, Zhang S, Liang Z, et al.
Biomed Pharmacother
. 2024 Jan;
171:116166.
PMID: 38244329
Osteoporosis is a systemic disease characterized by an imbalance in bone homeostasis, where osteoblasts fail to fully compensate for the bone resorption induced by osteoclasts. Corylifol A, a flavonoid extracted...
8.
Teng H, Yang B, Su Y, Chen J, Cui L, Sun R, et al.
Biomed Pharmacother
. 2023 Oct;
167:115605.
PMID: 37801901
The second most common cancer among men is prostate cancer, which is also the fifth leading reason for male cancer deaths worldwide. Bone metastases are the main factor affecting the...
9.
Xu M, Song D, Xie X, Qin Y, Huang J, Wang C, et al.
iScience
. 2023 Sep;
26(10):107760.
PMID: 37720109
Osteoporosis is a prevalent systemic metabolic disease in modern society, in which patients often suffer from bone loss due to over-activation of osteoclasts. Currently, amelioration of bone loss through modulation...
10.
Xie X, Chen W, Xu M, Chen J, Yang T, Wang C, et al.
Cell Prolif
. 2023 Aug;
57(1):e13535.
PMID: 37551727
Periodontal disease and arthroplasty prosthesis loosening and destabilization are both associated with osteolysis, which is predominantly caused by abnormal bone resorption triggered by pro-inflammatory cytokines. Osteoclasts (OCs) are critical players...