Jun-Ichi Satoh
Overview
Explore the profile of Jun-Ichi Satoh including associated specialties, affiliations and a list of published articles.
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102
Citations
2288
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Recent Articles
1.
Filipello F, You S, Mirfakhar F, Mahali S, Bollman B, Acquarone M, et al.
Acta Neuropathol
. 2023 Apr;
145(6):749-772.
PMID: 37115208
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and frontotemporal dementia,...
2.
Masuda Y, Fujihara K, Hayashi S, Sasaki H, Kino Y, Kamauchi H, et al.
J Nat Prod
. 2021 Jun;
84(6):1748-1754.
PMID: 34100599
To develop drugs to treat Alzheimer's disease (AD) on the basis of the amyloid cascade hypothesis, the amyloid-β (Aβ) aggregation inhibitory activities of 110 extracts from mushrooms were evaluated by...
3.
Satoh J, Kino Y, Yanaizu M, Ishida T, Saito Y
Intractable Rare Dis Res
. 2020 Nov;
9(4):217-221.
PMID: 33139980
By combining genomic data and brain imaging data, a recent study has identified a novel gene named that participates in the formation of amyloid-β (Aβ) plaques and brain atrophy in...
4.
Korvatska O, Kiianitsa K, Ratushny A, Matsushita M, Beeman N, Chien W, et al.
Front Immunol
. 2020 Oct;
11:559342.
PMID: 33101276
The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer's disease (AD). To characterize processes affected by R47H,...
5.
Yanaizu M, Washizu C, Nukina N, Satoh J, Kino Y
Sci Rep
. 2020 Oct;
10(1):17995.
PMID: 33093587
Genetic variations of TREM2 have been implicated as a risk factor of Alzheimer's disease (AD). Recent studies suggest that the loss of TREM2 function compromises microglial responses to the accumulation...
6.
Satoh J, Kino Y, Yanaizu M, Ishida T, Saito Y
Intractable Rare Dis Res
. 2020 Jan;
8(4):260-265.
PMID: 31890453
We previously identified an evolutionarily conserved protein named transmembrane protein 119 (TMEM119) as the most reliable maker for human microglia. Recent studies showed that under homeostatic conditions, microglia intensely express...
7.
Yatsu G, Kino Y, Sasaki H, Satoh J, Kinoshita K, Koyama K
J Nat Prod
. 2019 Jun;
82(7):1797-1801.
PMID: 31244141
BACE1 inhibitory activity-guided fractionation of an extract of the fruiting body of yielded five novel meroterpenoids (-) and one known compound (; asiaticusin A). The structures of these compounds were...
8.
Satoh J, Kino Y, Yanaizu M, Ishida T, Saito Y
Intractable Rare Dis Res
. 2019 Jun;
8(2):120-128.
PMID: 31218162
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein first identified in low-metastatic human melanoma cell lines as a regulator of tumor growth. GPNMB is widely expressed...
9.
Morisawa N, Satoh H, Matsuyama M, Hayashi N, Adachi A, Satoh J, et al.
Nihon Naika Gakkai Zasshi
. 2019 Jan;
105(12):2432-2439.
PMID: 30646443
No abstract available.
10.
Satoh J, Kino Y, Yanaizu M, Ishida T, Saito Y
Intractable Rare Dis Res
. 2018 Dec;
7(4):251-257.
PMID: 30560017
Gamma-interferon-inducible lysosomal thiol reductase (GILT), expressed in antigen-presenting cells (APCs), facilitates the reduction of disulfide bonds of endocytosed proteins in the endocytic pathway and they are further processed for presentation...