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Julika Neumann

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Articles 17
Citations 173
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Recent Articles
1.
Staels F, Bucken L, De Vuyst L, Willemsen M, Van Nieuwenhove E, Gerbaux M, et al.
Front Immunol . 2024 Jun; 15:983686. PMID: 38827742
Recently, OTULIN haploinsufficiency was linked to enhanced susceptibility to infections accompanied by local necrosis and systemic inflammation. The pathogenesis observed in haploinsufficient patients differs from the hyperinflammation seen in classical...
2.
Staniek J, Kalina T, Andrieux G, Boerries M, Janowska I, Fuentes M, et al.
Sci Immunol . 2024 Jan; 9(91):eadj5948. PMID: 38215192
Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with mutations (ALPS-FAS), but paradoxically, fewer conventional memory cells differentiate from FAS-expressing germinal center...
3.
Gerbaux M, Roos E, Willemsen M, Staels F, Neumann J, Bucken L, et al.
J Clin Immunol . 2023 May; 43(6):1393-1402. PMID: 37156988
Purpose: FOXP3 deficiency results in severe multisystem autoimmunity in both mice and humans, driven by the absence of functional regulatory T cells. Patients typically present with early and severe autoimmune...
4.
Willemsen M, Barber J, Van Nieuwenhove E, Staels F, Gerbaux M, Neumann J, et al.
J Allergy Clin Immunol . 2023 Feb; 152(1):266-277. PMID: 36841265
Background: Severe congenital neutropenia presents with recurrent infections early in life as a result of arrested granulopoiesis. Multiple genetic defects are known to block granulocyte differentiation; however, a genetic cause...
5.
Roca C, Burton O, Neumann J, Tareen S, Whyte C, Gergelits V, et al.
Cell Rep Methods . 2023 Feb; 3(1):100390. PMID: 36814837
The advent of high-dimensional single-cell data has necessitated the development of dimensionality-reduction tools. t-Distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation and projection (UMAP) are the two most frequently...
6.
Neumann J, Van Nieuwenhove E, Terry L, Staels F, Knebel T, Welkenhuyzen K, et al.
Cell Mol Immunol . 2022 Dec; 20(1):114. PMID: 36471115
No abstract available.
7.
Terry L, Arige V, Neumann J, Wahl A, Knebel T, Chaffer J, et al.
iScience . 2022 Nov; 25(12):105523. PMID: 36444295
Mutations in all subtypes of the inositol 1,4,5-trisphosphate receptor Ca release channel are associated with human diseases. In this report, we investigated the functionality of three neuropathy-associated missense mutations in...
8.
Willemsen M, Staels F, Gerbaux M, Neumann J, Schrijvers R, Meyts I, et al.
J Allergy Clin Immunol . 2022 Nov; 151(2):345-360. PMID: 36395985
Inborn errors of immunity are a heterogeneous group of monogenic immunologic disorders caused by mutations in genes with critical roles in the development, maintenance, or function of the immune system....
9.
Neumann J, Van Nieuwenhove E, Terry L, Staels F, Knebel T, Welkenhuyzen K, et al.
Cell Mol Immunol . 2022 Oct; 20(1):11-25. PMID: 36302985
Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IPR), a homo- or heterotetramer of the...
10.
Staels F, de Keukeleere K, Kinnunen M, Keskitalo S, Lorenzetti F, Vanmeert M, et al.
Front Immunol . 2022 Oct; 13:973543. PMID: 36203612
NFKB1 haploinsufficiengcy was first described in 2015 in three families with common variable immunodeficiency (CVID), presenting heterogeneously with symptoms of increased infectious susceptibility, skin lesions, malignant lymphoproliferation and autoimmunity. The...