Juliette Fremaux
Overview
Explore the profile of Juliette Fremaux including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
117
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Recent Articles
1.
Cussol L, Mauran-Ambrosino L, Buratto J, Belorusova A, Neuville M, Osz J, et al.
Angew Chem Int Ed Engl
. 2020 Sep;
60(5):2296-2303.
PMID: 32935897
Efficient optimization of a peptide lead into a drug candidate frequently needs further transformation to augment properties such as bioavailability. Among the different options, foldamers, which are sequence-based oligomers with...
2.
Fremaux J, Venin C, Mauran L, Zimmer R, Koensgen F, Rognan D, et al.
Chem Sci
. 2020 Feb;
10(42):9872-9879.
PMID: 32015811
The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of α-amino...
3.
Fremaux J, Venin C, Mauran L, Zimmer R, Guichard G, Goudreau S
Nat Commun
. 2019 Feb;
10(1):924.
PMID: 30804332
Peptides have gained so much attention in the last decade that they are now part of the main strategies, with small molecules and biologics, for developing new medicines. Despite substantial...
4.
Collie G, Pulka-Ziach K, Lombardo C, Fremaux J, Rosu F, Decossas M, et al.
Nat Chem
. 2015 Oct;
7(11):871-8.
PMID: 26492006
The design and construction of biomimetic self-assembling systems is a challenging yet potentially highly rewarding endeavour that contributes to the development of new biomaterials, catalysts, drug-delivery systems and tools for...
5.
Fremaux J, Mauran L, Pulka-Ziach K, Kauffmann B, Odaert B, Guichard G
Angew Chem Int Ed Engl
. 2015 Jul;
54(34):9816-20.
PMID: 26136402
Short α-peptides with less than 10 residues generally display a low propensity to nucleate stable helical conformations. While various strategies to stabilize peptide helices have been previously reported, the ability...
6.
Wechsel R, Maury J, Fremaux J, France S, Guichard G, Clayden J
Chem Commun (Camb)
. 2014 Oct;
50(95):15006-9.
PMID: 25327885
The ability of urea-linked oligomers of achiral diamines (achiral analogues of the well-established chiral oligourea foldamers) to adopt helical conformations was explored spectroscopically. Up to four achiral units were ligated...
7.
Fremaux J, Kauffmann B, Guichard G
J Org Chem
. 2014 May;
79(12):5494-502.
PMID: 24810879
The synthesis and conformational analysis of aliphatic oligoureas containing multiple adjacent N-alkylated units derived from proline (i.e., Pro(u)) are reported. The insertion of trisubstituted ureas in the main chain of...
8.
Fremaux J, Dolain C, Kauffmann B, Clayden J, Guichard G
Chem Commun (Camb)
. 2013 Jul;
49(67):7415-7.
PMID: 23862177
The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous...
9.
Fremaux J, Fischer L, Arbogast T, Kauffmann B, Guichard G
Angew Chem Int Ed Engl
. 2011 Oct;
50(48):11382-5.
PMID: 21976436
No abstract available.