Julie C Savage
Overview
Explore the profile of Julie C Savage including associated specialties, affiliations and a list of published articles.
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26
Citations
1648
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Recent Articles
1.
Vecchiarelli H, Bisht K, Sharma K, Novak S, Traetta M, Garcia-Segura M, et al.
bioRxiv
. 2024 Oct;
PMID: 39463930
This study examined dark microglia-a state linked to central nervous system pathology and neurodegeneration-during postnatal development in the mouse ventral hippocampus, finding that dark microglia interact with blood vessels and...
2.
Carrier M, Robert M, St-Pierre M, Gonzalez Ibanez F, de Andrade E, Laroche A, et al.
iScience
. 2024 Jul;
27(7):110037.
PMID: 39021809
Although the roles of embryonic yolk sac-derived, resident microglia in neurodevelopment were extensively studied, the possible involvement of bone marrow-derived cells remains elusive. In this work, we used a fate-mapping...
3.
Bolton J, Short A, Othy S, Kooiker C, Shao M, Gunn B, et al.
Cell Rep
. 2022 Mar;
38(13):110600.
PMID: 35354026
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit maturation, provoking these enduring vulnerabilities. We...
4.
Bordeleau M, Fernandez de Cossio L, Lacabanne C, Savage J, Vernoux N, Chakravarty M, et al.
Brain Behav Immun Health
. 2021 Sep;
15:100281.
PMID: 34589781
Prenatal exposure to maternal high-fat diet (mHFD) acts as a risk factor for various neurodevelopmental alterations in the progeny. Recent studies in mice revealed that mHFD results in both neuroinflammation...
5.
Picard K, Bisht K, Poggini S, Garofalo S, Golia M, Basilico B, et al.
Brain Behav Immun
. 2021 Aug;
97:423-439.
PMID: 34343616
Chronic psychological stress is one of the most important triggers and environmental risk factors for neuropsychiatric disorders. Chronic stress can influence all organs via the secretion of stress hormones, including...
6.
Subramanian J, Savage J, Tremblay M
Front Cell Neurosci
. 2021 Jan;
14:592607.
PMID: 33408613
Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial Alzheimer's...
7.
Bordeleau M, Lacabanne C, Fernandez de Cossio L, Vernoux N, Savage J, Gonzalez-Ibanez F, et al.
J Neuroinflammation
. 2020 Sep;
17(1):264.
PMID: 32891154
Background: Maternal nutrition is critical for proper fetal development. While increased nutrient intake is essential during pregnancy, an excessive consumption of certain nutrients, like fat, can lead to long-lasting detrimental...
8.
Awogbindin I, Ishola I, St-Pierre M, Carrier M, Savage J, Di Paolo T, et al.
Neurosci Lett
. 2020 Jun;
735:135164.
PMID: 32561452
Parkinson's disease (PD) is the most widespread movement disorder with a prevalence of 1 in 1000 individuals above 60 years of age. Until now, understanding the pathological mechanisms of PD...
9.
Savage J, St-Pierre M, Carrier M, El Hajj H, Novak S, Sanchez M, et al.
J Neuroinflammation
. 2020 Apr;
17(1):98.
PMID: 32241286
Background: Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation...
10.
Savage J, St-Pierre M, Hui C, Tremblay M
Front Neurosci
. 2020 Jan;
13:1340.
PMID: 31920505
Sickness behavior is a set of behavioral changes induced by infections and mediated by pro-inflammatory cytokines. It is characterized by fatigue, decreased appetite and weight loss, changes in sleep patterns,...