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Julian A Abrams

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Articles 136
Citations 3421
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Recent Articles
1.
Park H, Lynch E, Tillman A, Lewis K, Jin Z, Uhlemann A, et al.
Crit Care . 2025 Jan; 29(1):21. PMID: 39806400
Background: Patients admitted to the intensive care unit (ICU) often have gut colonization with pathogenic bacteria and such colonization is associated with increased risk for death and infection. We conducted...
2.
Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, et al.
Biomolecules . 2024 Sep; 14(9). PMID: 39334892
Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco's Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal for...
3.
Kumar A, Gwalani P, Iyer P, Wang K, Falk G, Ginsberg G, et al.
Clin Transl Gastroenterol . 2024 Aug; 15(10):e1. PMID: 39166758
Introduction: Reflux bile acids are believed to promote esophageal adenocarcinoma (EAC), but the role of systemic bile acids is unknown. This study aimed to assess associations between systemic bile acids...
4.
Radani N, Metwaly A, Reitmeier S, Baumeister T, Ingermann J, Horstmann J, et al.
Gastro Hep Adv . 2024 Aug; 1(5):755-766. PMID: 39131856
Background And Aims: Esophageal adenocarcinoma (EAC) incidence has risen dramatically in the Western countries over the past decades. The underlying reasons are incompletely understood, and shifts in the esophageal microbiome...
5.
Malick A, Ferris J, Hur C, Abrams J, Soroush A
Clin Transl Gastroenterol . 2024 Jul; 15(8):e00745. PMID: 39007497
Introduction: Current strategies for upper gastrointestinal (UGI) cancer screening primarily target cancer-specific risk, with the strongest focus on esophageal adenocarcinoma (EAC). However, all UGI cancers are amendable to screening and...
6.
Kumar A, Rara M, Yu M, Wen K, Grady W, Chak A, et al.
Clin Transl Gastroenterol . 2024 Jul; 15(8):e00751. PMID: 39007490
Introduction: Early neoplastic progression of Barrett's esophagus (BE) is often treated with endoscopic therapy. Although effective, some patients are refractory to therapy or recur after apparent eradication of the BE....
7.
Baumeister T, Proano-Vasco A, Metwaly A, Kleigrewe K, Kuznetsov A, Schomig L, et al.
bioRxiv . 2024 Jun; PMID: 38915718
Background: The incidence of Barrett esophagus (BE) and Gastroesophageal Adenocarcinoma (GEAC) correlates with obesity and a diet rich in fat. Bile acids (BA) support fat digestion and undergo microbial metabolization...
8.
Shimonosono M, Morimoto M, Hirose W, Tomita Y, Matsuura N, Flashner S, et al.
bioRxiv . 2024 Jun; PMID: 38826379
Background: Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco's Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal...
9.
Iyer P, Slettedahl S, Mahoney D, Giakoumopoulos M, Olson M, Krockenberger M, et al.
Clin Gastroenterol Hepatol . 2024 Mar; 22(8):1596-1604.e4. PMID: 38513982
Background & Aims: Endoscopic Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Nonendoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker...
10.
Weh K, Howard C, Zhang Y, Tripp B, Clarke J, Howell A, et al.
JCI Insight . 2024 Feb; 9(6). PMID: 38329812
The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic bacteria in patients with gastroesophageal reflux disease, Barrett's esophagus, and esophageal adenocarcinoma (EAC). However, mechanisms...