Julia M Jansen
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Explore the profile of Julia M Jansen including associated specialties, affiliations and a list of published articles.
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13
Citations
579
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Recent Articles
1.
Steitz A, Schroder C, Knuth I, Keber C, Sommerfeld L, Finkernagel F, et al.
iScience
. 2023 Dec;
26(12):108401.
PMID: 38047087
A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma (HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems of primary human cells, we discovered that...
2.
Sommerfeld L, Knuth I, Finkernagel F, Pesek J, Nockher W, Jansen J, et al.
Cancers (Basel)
. 2022 Dec;
14(24).
PMID: 36551640
Metastasis of high-grade ovarian carcinoma (HGSC) is orchestrated by soluble mediators of the tumor microenvironment. Here, we have used transcriptomic profiling to identify lipid-mediated signaling pathways encompassing 41 ligand-synthesizing enzymes...
3.
Sommerfeld L, Finkernagel F, Jansen J, Wagner U, Nist A, Stiewe T, et al.
Clin Transl Med
. 2021 Nov;
11(11):e633.
PMID: 34841720
Background: Transcoelomic spread is the major route of metastasis of ovarian high-grade serous carcinoma (HGSC) with the omentum as the major metastatic site. Its unique tumour microenvironment with its large...
4.
Ojasalu K, Brehm C, Hartung K, Nischak M, Finkernagel F, Rexin P, et al.
Mol Oncol
. 2020 Jun;
14(9):2142-2162.
PMID: 32533757
A hallmark of ovarian high-grade serous carcinoma (HGSC) is its early and massive peritoneal dissemination via the peritoneal fluid. It is generally believed that tumor cells must breach the mesothelium...
5.
Steitz A, Steffes A, Finkernagel F, Unger A, Sommerfeld L, Jansen J, et al.
Cell Death Dis
. 2020 Apr;
11(4):249.
PMID: 32312959
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified...
6.
Graumann J, Finkernagel F, Reinartz S, Stief T, Brodje D, Renz H, et al.
Front Oncol
. 2019 Nov;
9:1150.
PMID: 31737572
A central reason behind the poor clinical outcome of patients with high-grade serous carcinoma (HGSC) of the ovary is the difficulty in reliably detecting early occurrence or recurrence of this...
7.
Finkernagel F, Reinartz S, Schuldner M, Malz A, Jansen J, Wagner U, et al.
Theranostics
. 2019 Oct;
9(22):6601-6617.
PMID: 31588238
The peritoneal fluid (ascites), replete with abundant tumor-promoting factors and extracellular vesicles (EVs) reflecting the tumor secretome, plays an essential role in ovarian high-grade serous carcinoma (HGSC) metastasis and immune...
8.
Reinartz S, Lieber S, Pesek J, Brandt D, Asafova A, Finkernagel F, et al.
Mol Oncol
. 2018 Oct;
13(2):185-201.
PMID: 30353652
The peritoneal fluid of ovarian carcinoma patients promotes cancer cell invasion and metastatic spread with lysophosphatidic acid (LPA) as a potentially crucial mediator. However, the origin of LPA in ascites...
9.
Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, et al.
Oncoimmunology
. 2018 May;
7(5):e1424672.
PMID: 29721385
The accumulation of intratumoral CD8 T cells is associated with the survival of high grade serous ovarian carcinoma patients, but it is unclear which CD8 T cell subsets contribute to...
10.
Vyas M, Reinartz S, Hoffmann N, Reiners K, Lieber S, Jansen J, et al.
Oncoimmunology
. 2017 Sep;
6(9):e1339854.
PMID: 28932639
The immune receptor NKG2D is predominantly expressed on NK cells and T cell subsets and confers anti-tumor activity. According to the current paradigm, immune surveillance is counteracted by soluble ligands...