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Julia Boix

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Recent Articles
1.
Boix J, Knuever J, Niehoff N, Sen A, Pla-Martin D, Baris O, et al.
J Invest Dermatol . 2024 Nov; PMID: 39580109
Epidermis is one of the most rapidly proliferating tissues in the body with high demands for adenosine triphosphate and cellular building blocks. In this study, we show that to meet...
2.
Sen A, Boix J, Pla-Martin D
Autophagy . 2023 Jan; 19(9):2609-2610. PMID: 36691806
Mitophagy and its variants are considered important salvage pathways to remove dysfunctional mitochondria. Non-canonical mitophagy, independent of autophagosome formation and including endosomal-dependent mitophagy, operate upon specific injury. In a recent...
3.
Sen A, Kallabis S, Gaedke F, Jungst C, Boix J, Nuchel J, et al.
Nat Commun . 2022 Nov; 13(1):6704. PMID: 36344526
Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that specific mtDNA damage leads to an exacerbated mtDNA...
4.
Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson J, et al.
Carcinogenesis . 2020 Apr; 41(12):1735-1745. PMID: 32255484
Functioning mitochondria are crucial for cancer metabolism, but aerobic glycolysis is still considered to be an important pathway for energy production in many tumor cells. Here we show that two...
5.
Bigas J, Sevilla L, Carceller E, Boix J, Perez P
Cell Death Dis . 2018 May; 9(6):588. PMID: 29789551
Endogenous and synthetic glucocorticoids (GCs) regulate epidermal development and combat skin inflammatory diseases. GC actions can be mediated through the GC receptor (GR) and/or the mineralocorticoid receptor (MR), highly homologous...
6.
Boix J, Nguyen V, Farman N, Aractingi S, Perez P
Exp Dermatol . 2017 Nov; 27(2):185-187. PMID: 29178328
We recently demonstrated that blockade of the mineralocorticoid receptor (MR) effectively ameliorated GC-induced skin atrophy in healthy human skin explants and epidermal MR knockout mice. However, whether MR blockade improves...
7.
Boix J, Bigas J, Sevilla L, Iacobone M, Citton M, Torresan F, et al.
Sci Rep . 2017 Nov; 7(1):15806. PMID: 29150654
Primary aldosteronism (PA) is a disease characterized by high aldosterone levels caused by benign adrenal tumors being the most frequent cause of secondary hypertension. Aldosterone plays vital physiological roles through...
8.
Boix J, Sevilla L, Saez Z, Carceller E, Perez P
J Invest Dermatol . 2016 Jul; 136(12):2417-2426. PMID: 27464843
Glucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases; however, adverse effects of chronic GC treatments limit their therapeutic use. GCs bind and activate the GC receptor and the...
9.
Boix J, Carceller E, Sevilla L, Marcos-Garces V, Perez P
Exp Dermatol . 2015 Aug; 25(1):69-71. PMID: 26268211
No abstract available.
10.
Sevilla L, Latorre V, Carceller E, Boix J, Vodak D, Mills I, et al.
Mol Cell Endocrinol . 2015 May; 412:281-9. PMID: 26001834
The glucocorticoid (GC) receptor (GR) and Kruppel-like factor Klf4 are transcription factors that play major roles in skin homeostasis. However, whether these transcription factors cooperate in binding genomic regulatory regions...