Jules A Westbrook
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Explore the profile of Jules A Westbrook including associated specialties, affiliations and a list of published articles.
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12
Citations
264
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Recent Articles
1.
Brown J, Westbrook J, Wood S
Cancer Inform
. 2019 Sep;
18:1176935119866842.
PMID: 31488945
Metastasis to bone occurs in over 70% of patients with advanced breast cancer resulting in skeletal complications, including pathological fractures, hypercalcaemia, and bone pain. Significant advances have been made in...
2.
Westbrook J, Wood S, Cairns D, McMahon K, Gahlaut R, Thygesen H, et al.
J Pathol
. 2018 Nov;
247(3):381-391.
PMID: 30426503
Skeletal metastasis occurs in around 75% of advanced breast cancers, with the disease incurable once cancer cells disseminate to bone, but there remains an unmet need for biomarkers to identify...
3.
Westbrook J, Cairns D, Peng J, Speirs V, Hanby A, Holen I, et al.
J Natl Cancer Inst
. 2016 Jan;
108(4).
PMID: 26757732
Background: Bone is the predominant site of metastasis from breast cancer, and recent trials have demonstrated that adjuvant bisphosphonate therapy can reduce bone metastasis development and improve survival. There is...
4.
Westbrook J, Noirel J, Brown J, Wright P, Evans C
Proteomics Clin Appl
. 2014 Dec;
9(3-4):295-300.
PMID: 25504339
Isobaric tags for relative and absolute quantitation (iTRAQ), Tandem Mass Tags (TMT) and related chemical tag reagents provide analytical platforms for quantitative proteomics applied to clinical samples. In this Viewpoint...
5.
Nutter F, Holen I, Brown H, Cross S, Evans C, Walker M, et al.
Endocr Relat Cancer
. 2014 Jan;
21(2):327-41.
PMID: 24413608
Advanced breast cancer is associated with the development of incurable bone metastasis. The two key processes involved, tumour cell homing to and subsequent colonisation of bone, remain to be clearly...
6.
Wood S, Westbrook J, Brown J
Cancer Treat Rev
. 2013 Aug;
40(1):139-52.
PMID: 23958309
Despite well-recognised advances in breast cancer treatment, there remain substantial numbers of patients who develop metastatic disease, of which up to 70% involves spread to bone, resulting in skeletal complications...
7.
Grassl J, Westbrook J, Robinson A, Boren M, Dunn M, Clyne R
Proteomics
. 2009 Oct;
9(20):4616-26.
PMID: 19824011
Sample degradation is a common problem in all types of proteomic analyses as it generates protein and peptide fragments that can interfere with analytical results. An important step in preventing...
8.
Robinson A, Westbrook J, English J, Boren M, Dunn M
Proteomics
. 2009 Aug;
9(19):4433-44.
PMID: 19688732
Protein degradation that occurs in tissue during post-mortem interval or sample preparation is problematic in quantitative analyses as confounding variables may arise. Ideally, such artefacts should be prevented by preserving...
9.
Cieslak A, Vogler A, Lafranchi-Tristem N, Dunn M, Westbrook J
Electrophoresis
. 2007 Jan;
28(4):535-44.
PMID: 17226756
In a proteomic approach using 2-DE, the changes in protein expression patterns in wing imaginal discs induced by hormone treatment have been studied. Here we show the response of butterfly...
10.
Westbrook J, Wheeler J, Wait R, Welson S, Dunn M
Electrophoresis
. 2006 Apr;
27(8):1547-55.
PMID: 16609934
The analysis of complex proteomes is undertaken using a variety of techniques and technologies such as 2-DE, surface-enhanced laser desorption ionisation, and various types of MS. In order to overcome...