Judit Erchegyi
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Explore the profile of Judit Erchegyi including associated specialties, affiliations and a list of published articles.
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23
Citations
460
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Recent Articles
1.
Larauche M, Erchegyi J, Miller C, Sim M, Rivier J, Behan D, et al.
Peptides
. 2022 Oct;
157:170881.
PMID: 36185037
Peptide CRF antagonists injected peripherally alleviate stress-induced visceral hypersensitivity (SIVH) to colorectal distension (CRD) in rodents. Here we further evaluated the dose and time-dependent inhibitory activity of several long-acting peptide...
2.
Menting J, Gajewiak J, MacRaild C, Chou D, Disotuar M, Smith N, et al.
Nat Struct Mol Biol
. 2016 Sep;
23(10):916-920.
PMID: 27617429
Insulins in the venom of certain fish-hunting cone snails facilitate prey capture by rapidly inducing hypoglycemic shock. One such insulin, Conus geographus G1 (Con-Ins G1), is the smallest known insulin...
3.
Erchegyi J, Wang L, Gulyas J, Samant M, Perrin M, Lewis K, et al.
J Med Chem
. 2016 Jan;
59(3):854-66.
PMID: 26789203
CRF mediates numerous stress-related endocrine, autonomic, metabolic, and behavioral responses. We present the synthesis and chemical and biological properties of astressin B analogues {cyclo(30-33)[D-Phe(12),Nle(21,38),C(α)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h/r-CRF(9-41)}. Out of 37 novel peptides, 17...
4.
Perrin M, Tan L, Vaughan J, Lewis K, Donaldson C, Miller C, et al.
J Pharmacol Exp Ther
. 2015 Mar;
353(2):307-17.
PMID: 25736419
The corticotropin-releasing factor (CRF) peptide family comprises the mammalian peptides CRF and the urocortins as well as frog skin sauvagine and fish urophyseal urotensin. Advances in understanding the roles of...
5.
Fani M, Braun F, Waser B, Beetschen K, Cescato R, Erchegyi J, et al.
J Nucl Med
. 2012 Aug;
53(9):1481-9.
PMID: 22851637
Chelated somatostatin agonists have been shown to be sensitive to N-terminal radiometal modifications, with Ga-DOTA agonists having significantly higher binding affinity than their Lu-, In-, and Y-DOTA correlates. Recently, somatostatin...
6.
Chatenet D, Cescato R, Waser B, Erchegyi J, Rivier J, Reubi J
EJNMMI Res
. 2012 Jan;
1(1):21.
PMID: 22214201
Background: Several peptide hormone receptors were identified that are specifically over-expressed on the cell surface of certain human tumors. For example, high incidence and density of the Y1 subtype of...
7.
Erchegyi J, Cescato R, Waser B, Rivier J, Reubi J
J Med Chem
. 2011 Aug;
54(17):5981-7.
PMID: 21806016
Despite 3 decades of focused chemical, biological, structural, and clinical developments, unusual properties of somatostatin (SRIF, 1) analogues are still being uncovered. Here we report the unexpected functional properties of...
8.
Reubi J, Erchegyi J, Cescato R, Waser B, Rivier J
Eur J Nucl Med Mol Imaging
. 2010 Apr;
37(8):1551-8.
PMID: 20396884
Purpose: Peptide receptor targeting has become an increasingly attractive method to target tumors diagnostically and radiotherapeutically. Peptides linked to a variety of chelators have been developed for this purpose. They...
9.
Erchegyi J, Cescato R, Grace C, Waser B, Piccand V, Hoyer D, et al.
J Med Chem
. 2009 Apr;
52(9):2733-46.
PMID: 19351180
The proposed sst(1) pharmacophore (J. Med. Chem. 2005, 48, 523-533) derived from the NMR structures of a family of mono- and dicyclic undecamers was used to design octa-, hepta-, and...
10.
Grace C, Erchegyi J, Reubi J, Rivier J, Riek R
Biopolymers
. 2008 Jul;
89(12):1077-87.
PMID: 18655144
The three-dimensional NMR structures of seven octapeptide analogs of somatostatin (SRIF), based on octreotide, with the basic sequence H-Cpa/Phe2-c[DCys3-Xxx7-DTrp/DAph(Cbm)8-Lys9-Thr10-Cys14]-Yyy-NH2 (the numbering refers to the position in native SRIF), with Xxx7...