Juan Melendez-Alvarez
Overview
Explore the profile of Juan Melendez-Alvarez including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
61
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0
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Recent Articles
1.
Melendez-Alvarez J, He C, Zhang R, Kuang Y, Tian X
ACS Synth Biol
. 2021 Apr;
10(5):1227-1236.
PMID: 33915046
Growth feedback, the inherent coupling between the synthetic gene circuit and the host cell growth, could significantly change the circuit behaviors. Previously, a diverse array of emergent behaviors, such as...
2.
Zhang R, Goetz H, Melendez-Alvarez J, Li J, Ding T, Wang X, et al.
Nat Commun
. 2021 Feb;
12(1):853.
PMID: 33558556
Failure of modularity remains a significant challenge for assembling synthetic gene circuits with tested modules as they often do not function as expected. Competition over shared limited gene expression resources...
3.
Zhang R, Li J, Melendez-Alvarez J, Chen X, Sochor P, Goetz H, et al.
Nat Chem Biol
. 2020 Apr;
16(6):695-701.
PMID: 32251409
Growth-mediated feedback between synthetic gene circuits and host organisms leads to diverse emerged behaviors, including growth bistability and enhanced ultrasensitivity. However, the range of possible impacts of growth feedback on...