Juan M Hurle
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Explore the profile of Juan M Hurle including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
713
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Recent Articles
1.
Duarte-Olivenza C, Moran G, Hurle J, Lorda-Diez C, Montero J
Cell Death Dis
. 2023 Dec;
14(12):813.
PMID: 38071330
Micromass cultures of embryonic limb skeletal progenitors replicate the tissue remodelling processes observed during digit morphogenesis. Here, we have employed micromass cultures in an in vitro assay to study the...
2.
Duarte-Olivenza C, Hurle J, Montero J, Lorda-Diez C
Cells
. 2023 Jan;
12(1).
PMID: 36611968
Considering the importance of programmed cell death in the formation of the skeleton during embryonic development, the aim of the present study was to analyze whether regulated cell degeneration also...
3.
Montero J, Lorda-Diez C, Hurle J
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163078
The present paper proposes a new level of regulation of programmed cell death (PCD) in developing systems based on epigenetics. We argue against the traditional view of PCD as an...
4.
Sanchez-Fernandez C, Lorda-Diez C, Duarte-Olivenza C, Hurle J, Montero J
Cells
. 2021 Apr;
10(4).
PMID: 33921015
During limb formation in vertebrates with free digits, the interdigital mesoderm is eliminated by a massive degeneration process that involves apoptosis and cell senescence. The degradation process is preceded by...
5.
Lorda-Diez C, Duarte-Olivenza C, Hurle J, Montero J
Dev Dyn
. 2021 Apr;
251(1):125-136.
PMID: 33871876
Transforming growth factor beta (TGFβ) constitutes a large and evolutionarily conserved superfamily of secreted factors that play essential roles in embryonic development, cancer, tissue regeneration, and human degenerative pathology. Studies...
6.
Montero J, Lorda-Diez C, Hurle J
Front Cell Dev Biol
. 2020 Nov;
8:593761.
PMID: 33195267
Digits develop in the distal part of the embryonic limb primordium as radial prechondrogenic condensations separated by undifferentiated mesoderm. In a short time interval the interdigital mesoderm undergoes massive degeneration...
7.
Montero J, Lorda-Diez C, Sanchez-Fernandez C, Hurle J
Dev Dyn
. 2020 Aug;
250(9):1236-1247.
PMID: 32798262
Our aim is to critically review current knowledge of the function and regulation of cell death in the developing limb. We provide a detailed, but short, overview of the areas...
8.
Sanchez-Fernandez C, Lorda-Diez C, Hurle J, Montero J
Commun Biol
. 2020 Jun;
3(1):283.
PMID: 32504030
Digits shape is sculpted by interdigital programmed cell death during limb development. Here, we show that DNA breakage in the periphery of 5-methylcytosine nuclei foci of interdigital precursors precedes cell...
9.
Sanchez-Fernandez C, Lorda-Diez C, Garcia-Porrero J, Montero J, Hurle J
Cell Death Dis
. 2019 Apr;
10(5):347.
PMID: 31024001
The primordium of the limb contains a number of progenitors far superior to those necessary to form the skeletal components of this appendage. During the course of development, precursors that...
10.
Gibaja A, Aburto M, Pulido S, Collado M, Hurle J, Varela-Nieto I, et al.
Sci Rep
. 2019 Apr;
9(1):5912.
PMID: 30976015
Embryonic development requires the coordinated regulation of apoptosis, survival, autophagy, proliferation and differentiation programs. Senescence has recently joined the cellular processes required to master development, in addition to its well-described...