Joyce A DeLeo
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Explore the profile of Joyce A DeLeo including associated specialties, affiliations and a list of published articles.
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46
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2864
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Recent Articles
1.
Landry R, Martinez E, DeLeo J, Romero-Sandoval E
J Pain
. 2012 Aug;
13(9):836-48.
PMID: 22901764
Unlabelled: Peripheral nerve injury generally results in spinal neuronal and glial plastic changes associated with chronic behavioral hypersensitivity. Spinal mitogen-activated protein kinases (MAPKs), eg, p38 or extracellular signal-regulated kinases (ERKs),...
2.
Ndong C, Landry R, DeLeo J, Romero-Sandoval E
Mol Pain
. 2012 May;
8:34.
PMID: 22540262
Background: Neuropathic pain due to nerve injury is one of the most difficult types of pain to treat. Following peripheral nerve injury, neuronal and glial plastic changes contribute to central...
3.
Landry R, Jacobs V, Romero-Sandoval E, DeLeo J
Exp Neurol
. 2011 Nov;
234(2):340-50.
PMID: 22119425
There is a growing body of preclinical evidence for the potential involvement of glial cells in neuropathic pain conditions. Several glial-targeted agents are in development for the treatment of pain...
4.
Alkaitis M, Solorzano C, Landry R, Piomelli D, DeLeo J, Romero-Sandoval E
PLoS One
. 2010 Jun;
5(5):e10891.
PMID: 20531936
Background: An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood....
5.
Romero-Sandoval E, Horvath R, Landry R, DeLeo J
Mol Pain
. 2009 May;
5:25.
PMID: 19476641
Background: Cannabinoid receptor type 2 (CBR2) inhibits microglial reactivity through a molecular mechanism yet to be elucidated. We hypothesized that CBR2 activation induces an anti-inflammatory phenotype in microglia by inhibiting...
6.
Horvath R, DeLeo J
J Neurosci
. 2009 Jan;
29(4):998-1005.
PMID: 19176808
Opioids, although fundamental to the treatment of pain, are limited in efficacy by side effects including tolerance and hyperalgesia. Using an in vitro culture system, we report that morphine increased...
7.
Horvath R, Nutile-McMenemy N, Alkaitis M, DeLeo J
J Neurochem
. 2008 Aug;
107(2):557-69.
PMID: 18717813
Microglial cells are hematopoietically derived monocytes of the CNS and serve important neuromodulatory, neurotrophic, and neuroimmune roles. Following insult to the CNS, microglia develop a reactive phenotype, migrate to the...
8.
Romero-Sandoval E, Horvath R, DeLeo J
Curr Opin Investig Drugs
. 2008 Jul;
9(7):726-34.
PMID: 18600578
Chronic pain is the most difficult type of pain to treat. Previously, the development of analgesics has focused on neuronal targets; however, current analgesics are only modestly effective, have significant...
9.
Romero-Sandoval A, Chai N, Nutile-McMenemy N, DeLeo J
Brain Res
. 2008 Jun;
1219:116-26.
PMID: 18538310
The treatment of acute and chronic pain is still deficient. The modulation of glial cells may provide novel targets to treat pain. We hypothesize that astrocytes and microglia participate in...
10.
Romero-Sandoval A, Nutile-McMenemy N, DeLeo J
Anesthesiology
. 2008 Mar;
108(4):722-34.
PMID: 18362605
Background: Cannabinoids induce analgesia by acting on cannabinoid receptor (CBR) types 1 and/or 2. However, central nervous system side effects and antinociceptive tolerance from CBR1 limit their clinical use. CBR2...