Joy K Roche
Overview
Explore the profile of Joy K Roche including associated specialties, affiliations and a list of published articles.
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12
Citations
188
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Recent Articles
1.
Farmer C, Roach E, Bice L, Falgout M, Mata K, Roche J, et al.
J Neural Transm (Vienna)
. 2023 May;
130(7):949-965.
PMID: 37193867
A preponderance of evidence suggests that the hippocampus is a key region of dysfunction in schizophrenia. Neuroimaging and other studies indicate a relationship between hippocampal dysfunction and the degree of...
2.
Brown N, Roche J, Farmer C, Roberts R
J Neural Transm (Vienna)
. 2023 Feb;
130(4):561-573.
PMID: 36735096
The dopamine hypothesis of schizophrenia suggests that psychotic symptoms originate from dysregulation of dopaminergic activity, which may be controlled by upstream innervation. We hypothesized that we would find anatomical evidence...
3.
Roberts R, McCollum L, Schoonover K, Mabry S, Roche J, Lahti A
Schizophr Res
. 2020 Feb;
249:4-15.
PMID: 32014360
The aim of this paper is to summarize ultrastructural evidence for glutamatergic dysregulation in several linked regions in postmortem schizophrenia brain. Following a brief summary of glutamate circuitry and how...
4.
Walker C, Roche J, Sinha V, Roberts R
Schizophr Res
. 2017 Dec;
197:209-218.
PMID: 29274737
Schizophrenia is a severe mental illness affecting approximately 1% of the population worldwide. Despite its prevalence, the cause remains unknown, and treatment is not effective in all patients. Dopamine is...
5.
McCollum L, Walker C, Roche J, Roberts R
Schizophr Bull
. 2015 Mar;
41(5):1123-32.
PMID: 25817135
The cause of schizophrenia (SZ) is unknown and no single region of the brain can be pinpointed as an area of primary pathology. Rather, SZ results from dysfunction of multiple...
6.
Gandy J, Melendez-Ferro M, Bijur G, Van Leuven F, Roche J, Lechat B, et al.
Synapse
. 2013 Feb;
67(6):313-27.
PMID: 23390016
Glycogen synthase kinase-3β (GSK3β) activity has been previously linked to Alzheimer's disease (AD) by its phosphorylation of tau and activation by amyloid. GSK3β intracellular distribution is important in regulating its...
7.
McCollum L, Roche J, Roberts R
Synapse
. 2011 Oct;
66(3):204-19.
PMID: 22034050
Within the basal ganglia, the functionally defined region referred to as the striatum contains a subset of GABAergic medium spiny neurons expressing the neuropeptide enkephalin. Although the major features of...
8.
Roberts R, Roche J, Conley R, Lahti A
Synapse
. 2009 Feb;
63(6):520-30.
PMID: 19226604
The typical symptoms of schizophrenia (SZ) are psychotic symptoms (hallucinations, delusions, disorders of thought or speech, grossly disorganized behavior) as well as cognitive impairments and negative symptoms. Not all patients...
9.
Roberts R, Roche J, Conley R
Synapse
. 2008 May;
62(8):616-27.
PMID: 18509852
Subjects with schizophrenia (SZ) have an increased density of synapses characteristic of corticostriatal or thalamostriatal glutamatergic inputs in the caudate matrix and putamen patches. SZ is a heterogeneous disease in...
10.
Roberts R, Roche J, Conley R
Neurobiol Dis
. 2005 Oct;
20(2):324-35.
PMID: 16242639
The striatum processes motor, cognitive, and limbic circuitry. Striatal patch and matrix compartments are organized differently in many aspects including connectivity. Abnormalities in either compartment could have different functional consequences....