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Joske Millecam

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Articles 11
Citations 97
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Recent Articles
1.
Stroobant L, Croubels S, Dhondt L, Millecam J, De Baere S, Gasthuys E, et al.
Animals (Basel) . 2020 Jun; 10(6). PMID: 32545683
The aim of the current study was to investigate the simultaneous measurement of plasma p-aminohippuric acid (PAH) clearance as a potential marker to assess effective renal plasma flow (eRPF) and...
2.
Kutle L, Ljuma Skupnjak L, Vrdoljak A, Jankovic D, Jan Boelm G, Kelemen F, et al.
Viral Immunol . 2020 Jun; 33(8):555-564. PMID: 32522104
Infectious bronchitis (IB) is a highly contagious viral disease of chickens, known to cause severe economic losses. Vaccination against IB virus (IBV) is an important control measure against the disease....
3.
Engbers A, Flint R, Voller S, de Klerk J, Reiss I, Andriessen P, et al.
Br J Clin Pharmacol . 2020 Apr; 86(10):2028-2039. PMID: 32250464
Aims: Racemic ibuprofen is widely used for the treatment of preterm neonates with patent ductus arteriosus. Currently used bodyweight-based dosing guidelines are based on total ibuprofen, while only the S-enantiomer...
4.
Millecam J, De Baere S, Croubels S, Devreese M
Front Pharmacol . 2019 Jul; 10:712. PMID: 31316382
The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in...
5.
Millecam J, van Bergen T, Devreese M, Schauvliege S, Martens A, Chiers K, et al.
Lab Anim . 2019 Jun; 54(3):261-271. PMID: 31242071
The use of juvenile conventional pigs as a preclinical animal model to perform pharmacokinetic (PK), pharmacodynamic (PD) and safety studies for the paediatric population is increasing. Repetitive oral administration of...
6.
Schelstraete W, De Clerck L, Govaert E, Millecam J, Devreese M, Deforce D, et al.
Sci Rep . 2019 Jun; 9(1):9233. PMID: 31239454
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in...
7.
Millecam J, van Bergen T, Schauvliege S, Antonissen G, Martens A, Chiers K, et al.
Front Pharmacol . 2019 May; 10:505. PMID: 31143123
Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studies, but also to gain knowledge...
8.
Millecam J, De Clerck L, Govaert E, Devreese M, Gasthuys E, Schelstraete W, et al.
Front Pharmacol . 2018 Jun; 9:470. PMID: 29867477
Since the implementation of several legislations to improve pediatric drug research, more pediatric clinical trials are being performed. In order to optimize these pediatric trials, adequate preclinical data are necessary,...
9.
Gasthuys E, Vermeulen A, Croubels S, Millecam J, Schauvliege S, van Bergen T, et al.
Front Pharmacol . 2018 Feb; 9:41. PMID: 29445339
Desmopressin is used to treat primary nocturnal enuresis in children. Over the years, various formulations of desmopressin were commercialized of which the sublingual melt tablet is preferred in the pediatric...
10.
Gasthuys E, Devreese M, Millecam J, Sys S, Vanderperren K, Delanghe J, et al.
Front Pharmacol . 2017 Jul; 8:431. PMID: 28706488
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation. Over the years, pigs were presented as a potential...