Joshua W McCausland
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Explore the profile of Joshua W McCausland including associated specialties, affiliations and a list of published articles.
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12
Citations
192
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Recent Articles
1.
Zhang J, Takacs C, McCausland J, Mueller E, Buron J, Thappeta Y, et al.
J Bacteriol
. 2025 Feb;
:e0045724.
PMID: 39950812
The Lyme disease agent is a polyploid bacterium with a segmented genome in which both the chromosome and over 20 distinct plasmids are present in multiple copies per cell. This...
2.
McCausland J, Kloos Z, Irnov I, Sonnert N, Zhou J, Putnick R, et al.
bioRxiv
. 2025 Jan;
PMID: 39829805
The spirochete causes Lyme disease. In some patients, an excessive, dysregulated proinflammatory immune response can develop in joints leading to persistent arthritis. In such patients, persistence of antigenic peptidoglycan (PG)...
3.
McQuillen R, Perez A, Yang X, Bohrer C, Smith E, Chareyre S, et al.
Nat Commun
. 2024 Dec;
15(1):10746.
PMID: 39737933
Most bacteria lack membrane-enclosed organelles and rely on macromolecular scaffolds at different subcellular locations to recruit proteins for specific functions. Here, we demonstrate that the optogenetic CRY2-CIB1 system from Arabidopsis...
4.
Zhang J, Takacs C, McCausland J, Mueller E, Buron J, Thappeta Y, et al.
bioRxiv
. 2024 Nov;
PMID: 39554112
The Lyme disease agent is a polyploid bacterium with a segmented genome in which both the chromosome and over 20 distinct plasmids are present in multiple copies per cell. This...
5.
Schubert K, Braly M, Zhang J, Muscolo M, Lam H, Hug K, et al.
bioRxiv
. 2024 Oct;
PMID: 39416138
Many species of pathogenic bacteria harbor critical plasmid-encoded virulence factors, and yet the regulation of plasmid replication is often poorly understood despite playing a critical role in plasmid-encoded gene expression....
6.
Lyu Z, Yang X, Yahashiri A, Ha S, McCausland J, Chen X, et al.
bioRxiv
. 2024 Sep;
PMID: 39253420
The cell division protein FtsN was proposed to coordinate septal peptidoglycan (sPG) synthesis and degradation to ensure robust cell wall constriction without lethal lesions. Although the precise mechanism remains unclear,...
7.
Mahone C, Payne I, Lyu Z, McCausland J, Barrows J, Xiao J, et al.
J Cell Biol
. 2023 Nov;
223(2).
PMID: 38015166
To divide, bacteria must synthesize their peptidoglycan (PG) cell wall, a protective meshwork that maintains cell shape. FtsZ, a tubulin homolog, dynamically assembles into a midcell band, recruiting division proteins,...
8.
Lyu Z, Yahashiri A, Yang X, McCausland J, Kaus G, McQuillen R, et al.
Nat Commun
. 2022 Sep;
13(1):5751.
PMID: 36180460
FtsN plays an essential role in promoting the inward synthesis of septal peptidoglycan (sPG) by the FtsWI complex during bacterial cell division. How it achieves this role is unclear. Here...
9.
Nguyen T, Cheung G, Rigby K, Kamenyeva O, Kabat J, Sturdevant D, et al.
Nat Microbiol
. 2021 Dec;
7(1):62-72.
PMID: 34873293
Swift recruitment of phagocytic leucocytes is critical in preventing infection when bacteria breach through the protective layers of the skin. According to canonical models, this occurs via an indirect process...
10.
McCausland J, Yang X, Squyres G, Lyu Z, Bruce K, Lamanna M, et al.
Nat Commun
. 2021 Jan;
12(1):609.
PMID: 33504807
The FtsZ protein is a central component of the bacterial cell division machinery. It polymerizes at mid-cell and recruits more than 30 proteins to assemble into a macromolecular complex to...