Joshua Obermayer
Overview
Explore the profile of Joshua Obermayer including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
461
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Recent Articles
1.
Hunt S, Leibner Y, Mertens E, Barros-Zulaica N, Kanari L, Heistek T, et al.
Cereb Cortex
. 2022 Jul;
33(6):2857-2878.
PMID: 35802476
Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent but not human neocortex. We characterized synaptic transmission between pyramidal neurons in layers 2...
2.
Obermayer J, Luchicchi A, Heistek T, de Kloet S, Terra H, Bruinsma B, et al.
Nat Commun
. 2020 Feb;
11(1):794.
PMID: 32019922
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Obermayer J, Luchicchi A, Heistek T, de Kloet S, Terra H, Bruinsma B, et al.
Nat Commun
. 2019 Nov;
10(1):5280.
PMID: 31754098
Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite...
4.
Kroon T, Dawitz J, Kramvis I, Anink J, Obermayer J, Verhoog M, et al.
Front Cell Neurosci
. 2019 Jul;
13:315.
PMID: 31354435
Group I metabotropic glutamate receptors (mGluRs) mediate a range of signaling and plasticity processes in the brain and are of growing importance as potential therapeutic targets in clinical trials for...
5.
Goriounova N, Heyer D, Wilbers R, Verhoog M, Giugliano M, Verbist C, et al.
Elife
. 2018 Dec;
7.
PMID: 30561325
It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although grey matter thickness and activity of temporal and frontal cortical areas correlate with...
6.
Obermayer J, Heistek T, Kerkhofs A, Goriounova N, Kroon T, Baayen J, et al.
Nat Commun
. 2018 Oct;
9(1):4101.
PMID: 30291244
A variety of inhibitory pathways encompassing different interneuron types shape activity of neocortical pyramidal neurons. While basket cells (BCs) mediate fast lateral inhibition between pyramidal neurons, Somatostatin-positive Martinotti cells (MCs)...
7.
Thome C, Roth F, Obermayer J, Yanez A, Draguhn A, Egorov A
J Physiol
. 2018 Aug;
596(21):5237-5249.
PMID: 30144079
Key Points: Ectopic action potentials (EAPs) arise at distal locations in axonal fibres and are often associated with neuronal pathologies such as epilepsy or nerve injury, but they also occur...
8.
Obermayer J, Verhoog M, Luchicchi A, Mansvelder H
Front Neural Circuits
. 2017 Dec;
11:100.
PMID: 29276477
Acetylcholine (ACh) signaling shapes neuronal circuit development and underlies specific aspects of cognitive functions and behaviors, including attention, learning, memory and motivation. During behavior, activation of muscarinic and nicotinic acetylcholine...
9.
Luchicchi A, Mnie-Filali O, Terra H, Bruinsma B, de Kloet S, Obermayer J, et al.
Front Neural Circuits
. 2016 Sep;
10:70.
PMID: 27630545
Attending the sensory environment for cue detection is a cognitive operation that occurs on a time scale of seconds. The dorsal and ventral medial prefrontal cortex (mPFC) contribute to separate...
10.
Verhoog M, Obermayer J, Kortleven C, Wilbers R, Wester J, Baayen J, et al.
Nat Commun
. 2016 Sep;
7:12826.
PMID: 27604129
Individual cortical layers have distinct roles in information processing. All layers receive cholinergic inputs from the basal forebrain (BF), which is crucial for cognition. Acetylcholinergic receptors are differentially distributed across...