Joshua Martindale
Overview
Explore the profile of Joshua Martindale including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
112
Followers
0
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Recent Articles
1.
Thompson B, Martindale J, Metzger J
Am J Physiol Heart Circ Physiol
. 2016 May;
311(1):H36-43.
PMID: 27199134
The sarcomere is the functional unit of the heart. Alterations in sarcomere activation lead to disease states such as hypertrophic and restrictive cardiomyopathy (HCM/RCM). Mutations in many of the sarcomeric...
2.
Davis J, Yasuda S, Palpant N, Martindale J, Stevenson T, Converso K, et al.
J Mol Cell Cardiol
. 2012 Jun;
53(3):446-57.
PMID: 22683325
Restrictive cardiomyopathy (RCM) has been linked to mutations in the thin filament regulatory protein cardiac troponin I (cTnI). As the pathogenesis of RCM from genotype to clinical phenotype is not...
3.
Townsend D, Turner I, Yasuda S, Martindale J, Davis J, Shillingford M, et al.
J Clin Invest
. 2010 Mar;
120(4):1140-50.
PMID: 20234088
Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration caused by lack of the cytoskeletal protein dystrophin. Dystrophin deficiency causes muscle membrane instability, skeletal muscle wasting, cardiomyopathy,...
4.
Wang W, Martindale J, Metzger J
Gen Physiol Biophys
. 2010 Jan;
28 Spec No Focus:F3-6.
PMID: 20093724
Diastolic heart failure (DHF) is a clinical syndrome characterized by depressed myocardial relaxation performance and poor ventricular refilling. Defective intracellular calcium (Ca(2+)) handling underlies one of the fundamental mechanisms of...
5.
Turner I, Belema-Bedada F, Martindale J, Townsend D, Wang W, Palpant N, et al.
J Cardiovasc Transl Res
. 2009 Dec;
1(4):317-27.
PMID: 19956787
Acquired and inherited diseases of the heart represent a major health care issue in this country and throughout the World. Clinical medicine has made important advancements in the past quarter...
6.
Degousee N, Martindale J, Stefanski E, Cieslak M, Lindsay T, Fish J, et al.
Circ Res
. 2003 Mar;
92(7):757-64.
PMID: 12649265
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in delayed prostaglandin biosynthesis. The purpose of this study was to evaluate the role of the MAP kinase kinase 6 (MKK6)-p38 MAPK signaling cascade...