Joshua L Plotkin
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Explore the profile of Joshua L Plotkin including associated specialties, affiliations and a list of published articles.
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1193
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Recent Articles
1.
Matityahu L, Hobel Z, Berkowitz N, Malgady J, Gilin N, Plotkin J, et al.
bioRxiv
. 2024 Nov;
PMID: 39554102
Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the...
2.
Plotkin J, Graves S, Riessland M
Front Cell Neurosci
. 2024 Mar;
18:1385783.
PMID: 38486711
No abstract available.
3.
Malgady J, Baez A, Hobel Z, Jimenez K, Goldfried J, Prager E, et al.
Cell Rep
. 2023 Nov;
42(11):113384.
PMID: 37934666
Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at corticostriatal synapses, causes OCD-like motor behaviors in mice. While corticostriatal synaptic dysfunction...
4.
Chen A, Malgady J, Chen L, Shi K, Cheng E, Plotkin J, et al.
Nat Commun
. 2022 Oct;
13(1):5942.
PMID: 36209150
The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated in perceptual decision-making, transforming auditory stimuli to action outcomes. Despite its known connections to diverse neurological...
5.
Matityahu L, Malgady J, Schirelman M, Johansson Y, Wilking J, Silberberg G, et al.
Elife
. 2022 May;
11.
PMID: 35579422
Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output. This process is fine-tuned by striatal GABAergic interneurons (GINs), which receive...
6.
Prager E, Dorman D, Hobel Z, Malgady J, Blackwell K, Plotkin J
Neuron
. 2020 Oct;
108(6):1091-1102.e5.
PMID: 33080228
Corticostriatal synaptic integration is partitioned among striosome (patch) and matrix compartments of the dorsal striatum, allowing compartmentalized control of discrete aspects of behavior. Despite the significance of such organization, it's...
7.
Prager E, Chambers K, Plotkin J, McArthur D, Bandrowski A, Bansal N, et al.
Cancer Rep (Hoboken)
. 2020 Jul;
2(1):e1150.
PMID: 32721132
Progress in basic and clinical research is slowed when researchers fail to provide a complete and accurate report of how a study was designed, executed, and the results analyzed. Publishing...
8.
Cirnaru M, Melis C, Fanutza T, Naphade S, Tshilenge K, Muntean B, et al.
eNeuro
. 2019 Sep;
6(5).
PMID: 31541002
The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be classified into striosome, also known as patch, and matrix, based on neurochemical differences between the two compartments. At...
9.
Prager E, Plotkin J
J Neurosci Res
. 2019 Sep;
97(12):1503-1514.
PMID: 31489687
The striatum plays a central role in guiding numerous complex behaviors, ranging from motor control to action selection and reward learning. The diverse responsibilities of the striatum are reflected by...
10.
Carrillo-Reid L, Day M, Xie Z, Melendez A, Kondapalli J, Plotkin J, et al.
Elife
. 2019 Apr;
8.
PMID: 31017573
Huntington's disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better...