Joshua L Dunaief
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Explore the profile of Joshua L Dunaief including associated specialties, affiliations and a list of published articles.
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135
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4677
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Recent Articles
11.
Perzia B, Ying G, Dunaief J, Dunaief D
Am J Lifestyle Med
. 2022 Nov;
16(6):753-764.
PMID: 36389047
Serum C-reactive protein (CRP), a marker of systemic inflammation, is associated with increased risk for numerous inflammation-driven chronic diseases. A prior longitudinal study showed that the Low Inflammatory Foods Everyday...
12.
Perzia B, Ying G, Dunaief J, Dunaief D
Curr Dev Nutr
. 2022 Jun;
6(6):nzac095.
PMID: 35769450
Background: Ferritin is an iron-containing protein and acute-phase reactant, which may be elevated due to systemic iron overload or inflammation. Various diseases are associated with excess iron, but therapeutic iron...
13.
14.
Sterling J, Baumann B, Foshe S, Voigt A, Guttha S, Alnemri A, et al.
Cell Rep
. 2022 Jun;
39(11):110942.
PMID: 35705048
Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron...
15.
Zhang K, Baumann B, Song Y, Sterling J, Erler E, Guttha S, et al.
Exp Eye Res
. 2022 Mar;
218:109028.
PMID: 35271829
Iron accumulation has been implicated in degenerative retinal diseases. It can catalyze the production of damaging reactive oxygen species. Previous work has demonstrated iron accumulation in multiple retinal diseases, including...
16.
Liu Y, Bell B, Song Y, Zhang K, Anderson B, Axelsen P, et al.
Aging Cell
. 2022 Mar;
21(4):e13579.
PMID: 35257475
Oxidative stress plays a central role in age-related macular degeneration (AMD). Iron, a potent generator of hydroxyl radicals through the Fenton reaction, has been implicated in AMD. One easily oxidized...
17.
Liu Y, Baumann B, Song Y, Zhang K, Sterling J, Lakhal-Littleton S, et al.
Exp Eye Res
. 2022 Feb;
218:108988.
PMID: 35202704
Iron-induced oxidative stress can cause or exacerbate retinal degenerative diseases. Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous...
18.
Huang S, Liu C, Wang Z, Fu Z, Britton W, Blomfield A, et al.
Redox Biol
. 2022 Feb;
51:102261.
PMID: 35176707
Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular degeneration (AMD), often leading to photoreceptor degeneration and vision loss. Accumulated oxidative stress during aging contributes to RPE...
19.
Sterling J, Kam T, Guttha S, Park H, Baumann B, Mehrabani-Tabari A, et al.
Cell Rep
. 2022 Feb;
38(7):110358.
PMID: 35172141
α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson's disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation...
20.
Chuang J, Yang N, Nakajima N, Otsu W, Fu C, Yang H, et al.
Nat Commun
. 2022 Jan;
13(1):374.
PMID: 35042858
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark of dry AMD. An...